Results 41 to 50 of about 1,472,593 (206)

Pseudotype-based neutralization assays for influenza: a systematic analysis [PDF]

, 2015
The use of vaccination against the influenza virus remains the most effective method of mitigating the significant morbidity and mortality caused by this virus.
Ferrara, Francesca, Keith eGrehan, Temperton, Nigel J., George William Carnell, Craig Peter Thompson, Francesca eFerrara, Nigel James Temperton, Grehan, Keith, Carnell, George W., Thompson, Craig P., Francesca Ferrara, Keith Grehan   +11 more
core   +1 more source

Cross-sectional survey of older people's views related to influenza vaccine uptake [PDF]

, 2006
Background The population's views concerning influenza vaccine are important in maintaining high uptake of a vaccine that is required yearly to be effective.
Hanciles, S, Elizabeth Breeze, Astrid Fletcher, Hanciles, Smita, Breeze, E, Stirling, Sue, Sari Kovats, Fletcher Astrid, Punam Mangtani, Stirling, S, Mangtani, P, Stirling Sue, Fletcher, Astrid, Kovats, Sari, Hanciles Smita, Fletcher, A, Breeze, Elizabeth, Kovats Sari, Mangtani Punam, Kovats, S, Breeze Elizabeth, Sue Stirling, Mangtani, Punam, Smita Hanciles   +23 more
core   +2 more sources

Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins

Vaccines, 2019
Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza
Seyed Davoud Jazayeri, Chit Laa Poh
doaj   +1 more source

An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets

npj Vaccines, 2022
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality associated with H3N2-dominated influenza seasons.
Brianna L. Bullard, Jennifer DeBeauchamp, Matthew J. Pekarek, Erika Petro-Turnquist, Peter Vogel, Richard J. Webby, Eric A. Weaver   +6 more
doaj   +1 more source

Progress in the Development of Universal Influenza Vaccines [PDF]

Viruses, 2020
Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine ...
Wenqiang Sun, Tingrong Luo, Wenjun Liu, Jing Li   +3 more
openaire   +3 more sources

Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial [PDF]

, 2010
Background: Current conventional vaccination approaches do not induce potent CD8 T-cell responses for fighting mostly variable viral diseases such as influenza, avian influenza viruses or HIV.
van der Werf, Sylvie, Christine Katlama, Annika Vogt, Dominique Costagliola, Katlama, Christine, Sabrina Hadam, Behazine Combadière, Sterry, Wolfram, Vogt, Annika, Costagliola, Dominique, Autran, Brigitte, Blume-Peytav, Ulrike, Brice Mahé, Wolfram Sterry, Bonduelle, Olivia, Shlomo Staszewski, Ulrike Blume-Peytavi, Brigitte Autran, Olivia Bonduelle, Blume-Peytavi, Ulrike, Combadière, Behazine, Mahé, Brice, Hadam, Sabrina, Schaefer, Hans, Staszewski, Shlomo, Hans Schaefer, Sylvie van der Werf   +26 more
core   +2 more sources

The prospects and challenges of universal vaccines for influenza [PDF]

Trends in Microbiology, 2013
Vaccination is the most effective way to reduce the impact of epidemic as well as pandemic influenza. However, the licensed inactivated influenza vaccine induces strain-specific immunity and must be updated annually. When novel viruses appear, matched vaccines are not likely to be available in time for the first wave of a pandemic.
Kanta, Subbarao, Yumiko, Matsuoka
openaire   +2 more sources

Influenza and Universal Vaccine Research in China

Viruses, 2022
Influenza viruses usually cause seasonal influenza epidemics and influenza pandemics, resulting in acute respiratory illness and, in severe cases, multiple organ complications and even death, posing a serious global and human health burden. Compared with other countries, China has a large population base and a large number of influenza cases and deaths.
Jiali Li, Yifan Zhang, Xinglong Zhang, Longding Liu   +3 more
openaire   +3 more sources

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

mBio, 2015
Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics.
Louis M. Schwartzman, Andrea L. Cathcart, Lindsey M. Pujanauski, Li Qi, John C. Kash, Jeffery K. Taubenberger   +5 more
doaj   +1 more source

Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses

Frontiers in Microbiology, 2020
The extracellular domain of influenza M2 protein (M2e) is highly conserved and is a promising target for development of universal influenza vaccines. Here, we synthesized a peptide vaccine consisting of M2e epitope linked to a fibrillizing peptide, which
Qimin Wang, Yuling Zhang, Peng Zou, Meixiang Wang, Weihui Fu, Jialei She, Zhigang Song, Jianqing Xu, Jinghe Huang, Fan Wu   +9 more
doaj   +1 more source