The Quest for a Truly Universal Influenza Vaccine. [PDF]
Front Cell Infect Microbiol, 2019 There is an unmet public health need for a universal influenza vaccine (UIV) to provide broad and durable protection from influenza virus infections. The identification of broadly protective antibodies and cross-reactive T cells directed to influenza viral targets present a promising prospect for the development of a UIV.
Jang YH, Seong BL.
europepmc +5 more sources
A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases [PDF]
Journal of Infectious Diseases, 2018 Barney S. Graham +2 more
exaly +2 more sources
Age-specific vaccine effectiveness of seasonal 2010/2011 and pandemic influenza A(H1N1) 2009 vaccines in preventing influenza in the United Kingdom [PDF]
, 2013 An analysis was undertaken to measure age-specific vaccine effectiveness (VE) of 2010/11 trivalent seasonal influenza vaccine (TIV) and monovalent 2009 pandemic influenza vaccine (PIV) administered in 2009/2010.
Ellis, J. +15 more
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Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches
Viruses, 2020 Influenza is one of the top threats to public health. The best strategy to prevent influenza is vaccination. Because of the antigenic changes in the major surface antigens of influenza viruses, current seasonal influenza vaccines need to be updated every
Sijia Tang, Wandi Zhu, Bao-Zhong Wang
doaj +1 more source
Recent Progress in Recombinant Influenza Vaccine Development Toward Heterosubtypic Immune Response
Frontiers in Immunology, 2022 Flu, a viral infection caused by the influenza virus, is still a global public health concern with potential to cause seasonal epidemics and pandemics. Vaccination is considered the most effective protective strategy against the infection. However, given
Mark B. Carascal +3 more
doaj +1 more source
Assessment of the variability in influenza A(H1N1) vaccine effectiveness estimates dependent on outcome and methodological approach [PDF]
, 2011 Estimation of Influenza vaccine effectiveness (VE) varies with study design, clinical outcome 10 considered and statistical methodology used. By estimating VE using differing outcomes and 11 statistical methods on the same cohort of individuals the ...
Kavanagh, Kimberley +2 more
core +5 more sources
Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Frontiers in Microbiology, 2020 Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms ranging from mild to life-threatening. The vast majority of influenza virus infections in humans are observed during seasonal epidemics and occasional pandemics ...
Olivia A. Vogel, Balaji Manicassamy
doaj +1 more source
The Pathway to a Universal Influenza Vaccine [PDF]
Immunity, 2017 Development of a universal influenza vaccine is a research priority for the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health. To facilitate this goal, we convened a workshop in Rockville, Maryland to identify knowledge gaps in influenza research and develop strategies to fill them.
Paules, Catharine I. +4 more
openaire +3 more sources
Viruses, 2020 On average, there are 3–5 million severe cases of influenza virus infections globally each year. Seasonal influenza vaccines provide limited protection against divergent influenza strains.
Brigette N. Corder +3 more
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Universal Flu mRNA Vaccine: Promises, Prospects, and Problems
Vaccines, 2022 The seasonal flu vaccine is, essentially, the only known way to prevent influenza epidemics. However, this approach has limited efficacy due to the high diversity of influenza viruses. Several techniques could potentially overcome this obstacle. A recent
Andrei A. Deviatkin +5 more
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