Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence [PDF]
, 2013 Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody.
A Endo +51 more
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A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases [PDF]
Journal of Infectious Diseases, 2018 Diane J Post +2 more
exaly +2 more sources
Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Potential for a Universal Influenza Vaccine. [PDF]
Cold Spring Harb Perspect Biol, 2018 Development of optimal vaccines for influenza is challenging, in part as a result of the high antigenic variability in field strains associated with genetic shift from reassortment and genetic drift from point mutations. Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for neutralizing antibodies suggested the possibility that ...
Crowe JE.
europepmc +4 more sources
The Pathway to a Universal Influenza Vaccine [PDF]
Immunity, 2017 Development of a universal influenza vaccine is a research priority for the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health. To facilitate this goal, we convened a workshop in Rockville, Maryland to identify knowledge gaps in influenza research and develop strategies to fill them.
Paules, Catharine I. +4 more
openaire +3 more sources
Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches
Viruses, 2020 Influenza is one of the top threats to public health. The best strategy to prevent influenza is vaccination. Because of the antigenic changes in the major surface antigens of influenza viruses, current seasonal influenza vaccines need to be updated every
Sijia Tang, Wandi Zhu, Bao-Zhong Wang
doaj +1 more source
Recent Progress in Recombinant Influenza Vaccine Development Toward Heterosubtypic Immune Response
Frontiers in Immunology, 2022 Flu, a viral infection caused by the influenza virus, is still a global public health concern with potential to cause seasonal epidemics and pandemics. Vaccination is considered the most effective protective strategy against the infection. However, given
Mark B. Carascal +3 more
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Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine [PDF]
Vaccines, 2018 E Bridie Clemens +2 more
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Protection by universal influenza vaccine is mediated by memory CD4 T cells [PDF]
Vaccine, 2018 Sophie A Valkenburg +2 more
exaly +2 more sources
Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Frontiers in Microbiology, 2020 Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms ranging from mild to life-threatening. The vast majority of influenza virus infections in humans are observed during seasonal epidemics and occasional pandemics ...
Olivia A. Vogel, Balaji Manicassamy
doaj +1 more source
Is a universal influenza vaccine feasible? [PDF]
Ther Adv Vaccines Immunother, 2019 The influenza virus causes significant human morbidity and mortality annually and poses a pandemic threat. In addition, the virus frequently mutates, contributing to thousands of identified strains. Current influenza vaccine solutions are strain specific, target existing strains, and achieve only approximately 40% vaccine effectiveness (VE).
Phillipson JE +2 more
europepmc +5 more sources