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Prospects and Challenges in the Development of Universal Influenza Vaccines [PDF]
Vaccines, 2020 Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation influenza vaccines that can ...
Anders Madsen, Rebecca Jane Cox
doaj +5 more sources
Vaccines, 2018 The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes.
Sun-Young Sunwoo +12 more
doaj +3 more sources
The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine [PDF]
Frontiers in Immunology, 2018 Influenza viruses circulate worldwide causing annual epidemics that have a substantial impact on public health. This is despite vaccines being in use for over 70 years and currently being administered to around 500 million people each year.
Sophie A. Valkenburg +9 more
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Options and Obstacles for Designing a Universal Influenza Vaccine
Viruses, 2014 Since the discovery of antibodies specific to a highly conserved stalk region of the influenza virus hemagglutinin (HA), eliciting such antibodies has been considered the key to developing a universal influenza vaccine that confers broad-spectrum ...
Yo Han Jang, Baik Lin Seong
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Targeting Antigens for Universal Influenza Vaccine Development [PDF]
Viruses, 2021 Quyen-Thi Nguyen, Young-Ki Choi
exaly +2 more sources
Is It Possible? A Different Approach to Creating a Universal Influenza Vaccine [PDF]
mBio, 2015 The best way to combat influenza virus infection is to prevent it. However, the continual evolution of circulating influenza virus strains and the constant threat of newly emerging viruses forces the public health community to annually update seasonal ...
Stacey Schultz-Cherry
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Development of a Universal Influenza Vaccine. [PDF]
J Immunol, 2019 Abstract The severity of the 2017–18 influenza season, combined with the low efficacy for some vaccine components, highlights the need to improve our current seasonal influenza vaccine. Thus, the National Institute of Allergy and Infectious Diseases recently announced a strategic plan to improve current influenza vaccines and eventually ...
Estrada LD, Schultz-Cherry S.
europepmc +4 more sources
Biomimetic nanoparticles as universal influenza vaccine. [PDF]
Smart Mater Med, 2020 Pandemic virus infections pose a major public health threat globally. Much efforts have been devoted to suppress the virus, including vaccine prevention, autoimmunity enhancement, and anti-virus drugs treatment. Among these strategies, development of novel and improved vaccine technologies attracts broad attention as they can nip the virus outbreak in ...
Wang F, Chen G, Zhao Y.
europepmc +4 more sources
Influenza Vaccine Effectiveness and Progress Towards a Universal Influenza Vaccine. [PDF]
DrugsAt various times in recent decades, surges have occurred in optimism about the potential for universal influenza vaccines that provide strong, broad, and long-lasting protection and could substantially reduce the disease burden associated with seasonal influenza epidemics as well as the threat posed by pandemic influenza.
Cowling BJ, Okoli GN.
europepmc +3 more sources
The Quest for a Truly Universal Influenza Vaccine. [PDF]
Front Cell Infect Microbiol, 2019 There is an unmet public health need for a universal influenza vaccine (UIV) to provide broad and durable protection from influenza virus infections. The identification of broadly protective antibodies and cross-reactive T cells directed to influenza viral targets present a promising prospect for the development of a UIV.
Jang YH, Seong BL.
europepmc +5 more sources