Results 31 to 40 of about 1,472,593 (206)

Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine [PDF]

Vaccines, 2018
Sophie A Valkenburg, Carolien E van de Sandt, Bridie Clemens   +2 more
exaly   +2 more sources

Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Potential for a Universal Influenza Vaccine. [PDF]

Cold Spring Harb Perspect Biol, 2018
Development of optimal vaccines for influenza is challenging, in part as a result of the high antigenic variability in field strains associated with genetic shift from reassortment and genetic drift from point mutations. Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for neutralizing antibodies suggested the possibility that ...
Crowe JE.
europepmc   +4 more sources

M2e-Based Universal Influenza A Vaccines [PDF]

Vaccines, 2015
The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these ...
Lei Deng, Ki Cho, Walter Fiers, Xavier Saelens   +3 more
openaire   +4 more sources

Universal influenza vaccines: Shifting to better vaccines [PDF]

Vaccine, 2016
Influenza virus causes acute upper and lower respiratory infections and is the most likely, among known pathogens, to cause a large epidemic in humans. Influenza virus mutates rapidly, enabling it to evade natural and vaccine-induced immunity. Furthermore, influenza viruses can cross from animals to humans, generating novel, potentially pandemic ...
Berlanda Scorza, Francesco, Tsvetnitsky, Vadim, Donnelly, John J.   +2 more
openaire   +2 more sources

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]

, 2012
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N, Lang, Pierre-Olivier, Govind, Sheila, Aspinall R, Mendes A, Mendes, Aline, Socquet, Jennifer, Govind S, Socquet J, Assir, Noémie, Lang PO, Aspinall, Richard   +11 more
core   +1 more source

Improved adjuvanting of seasonal influenza vaccines: Pre-clinical studies of MVA-NP+M1 co-administration with inactivated influenza vaccine. [PDF]

, 2013
Licensed seasonal influenza vaccines induce antibody responses against influenza hemagglutinin that are limited in their ability to protect against different strains of influenza.
Gilbert, SC, Temperton, Nigel J., Charleston, Bryan, Molesti, E, Sarah C. Gilbert, Butter, Colin, Massimiliano Baratelli, Lambe, Teresa, Boyd, A, Mullarkey, CE, Charleston, B, Caitlin E. Mullarkey, Eleonora Molesti, Gilbert, Sarah, van Laarhoven, Arjan, Veronica Carr, B, van Laarhoven, A, Eric A. Lefevre, Molesti, Eleonora, Amy Boyd, Colin Butter, Mullarkey, Caitlin E, Gilbert, Sarah C, Lefevre, EA, B. Veronica Carr, Arjan van Laarhoven, Nigel J. Temperton, Lambe, T, Baratelli, M, Carr, B Veronica, Baratelli, Massimiliano, Lefevre, Eric A, Boyd, Amy, Temperton, NJ, Butter, C, Teresa Lambe, Bryan Charleston   +36 more
core   +1 more source

MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response. [PDF]

PLoS ONE, 2012
Influenza virus infection and the resulting complications are a significant global public health problem. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not cross-protective.
James S Testa, Vivekananda Shetty, Julie Hafner, Zacharie Nickens, Shivali Kamal, Gomathinayagam Sinnathamby, Ramila Philip   +6 more
doaj   +1 more source

Is a universal influenza vaccine feasible? [PDF]

Ther Adv Vaccines Immunother, 2019
The influenza virus causes significant human morbidity and mortality annually and poses a pandemic threat. In addition, the virus frequently mutates, contributing to thousands of identified strains. Current influenza vaccine solutions are strain specific, target existing strains, and achieve only approximately 40% vaccine effectiveness (VE).
Phillipson JE, Babecoff R, Ben-Yedidia T.   +2 more
europepmc   +5 more sources

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
Carnell, George, Temperton, Nigel J., Mallajosyula, VVA, Poon, Leo LM, Mallajosyula, V Vamsee Aditya, Temperton, N, Poon, LLM, Chin, Alex WH, Mallajosyula, VV, Chin, Alex W H, Carnell, G, Valkenburg, Sophie A, Li, OTW, Poon, Leo L M, Chin, WH, Mallajosyula, Vamsee Aditya V, Poon, LML, Li, Olive T W, Varadarajan, Raghavan, Doak, SA, Li, Olive TW, Temperton, Nigel, Chin, AWH, Valkenburg, SA, Varadarajan, R   +24 more
core   +1 more source

M2e-Based Influenza Vaccines with Nucleoprotein: A Review

Vaccines, 2021
Discovery of conserved antigens for universal influenza vaccines warrants solutions to a number of concerns pertinent to the currently licensed influenza vaccines, such as annual reformulation and mismatching with the circulating subtypes.
Mei Peng Tan, Wen Siang Tan, Noorjahan Banu Mohamed Alitheen, Wei Boon Yap   +3 more
doaj   +1 more source