mBio, 2015 Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics.
Louis M. Schwartzman +5 more
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Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses
Frontiers in Microbiology, 2020 The extracellular domain of influenza M2 protein (M2e) is highly conserved and is a promising target for development of universal influenza vaccines. Here, we synthesized a peptide vaccine consisting of M2e epitope linked to a fibrillizing peptide, which
Qimin Wang +9 more
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Influenza and memory T cells : how to awake the force [PDF]
, 2016 Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen +12 more
core +3 more sources
Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]
, 2016 There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico +9 more
core +2 more sources
mLife, 2023 Current influenza vaccines need to be updated annually owing to constant antigenic drift in the globular head of the viral surface hemagglutinin (HA) glycoprotein. The immunogenic subdominant stem domain of HA is highly conserved and can be recognized by
Yulei Li +5 more
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Preparing for the Next Influenza Pandemic: The Development of a Universal Influenza Vaccine. [PDF]
J Infect Dis, 2019 Crank MC, Mascola JR, Graham BS.
europepmc +4 more sources
Summertime, and the livin is easy: Winter and summer pseudoseasonal life expectancy in the United States [PDF]
, 2017 In temperate climates, mortality is seasonal with a winter-dominant pattern, due in part to pneumonia and influenza. Cardiac causes, which are the leading cause of death in the United States, are also winter-seasonal although it is not clear why ...
Ho, Tina, Noymer, Andrew
core +2 more sources
Nano/microparticle Formulations for Universal Influenza Vaccines [PDF]
The AAPS Journal, 2022 Influenza affects millions of people worldwide and can result in severe sickness and even death. The best method of prevention is vaccination; however, the seasonal influenza vaccine often suffers from low efficacy and requires yearly vaccination due to changes in strain and viral mutations.
Dylan A. Hendy +4 more
openaire +2 more sources
Factors associated with influenza vaccine uptake during a universal vaccination programme of preschool children in England and Wales: a cohort study [PDF]
, 2016 INTRODUCTION: Influenza vaccination through primary care has been recommended for all preschool children in the UK since 2013 as part of a universal immunisation programme. Vaccination is required annually and effectiveness varies by season.
Gilbert, R +3 more
core +1 more source
A human multi-epitope recombinant vaccinia virus as a universal T cell vaccine candidate against influenza virus. [PDF]
PLoS ONE, 2011 There is a need to develop a universal vaccine against influenza virus infection to avoid developing new formulations of a seasonal vaccine each year. Many of the vaccine strategies for a universal vaccine target strain-conserved influenza virus proteins,
Alan G Goodman +6 more
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