Results 21 to 30 of about 477,259 (212)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

De la gestion du temps d’études par les apprenants de la propédeutique de l’Université de Kinshasa [PDF]

open access: yesMouvements et Enjeux Sociaux, 2023
Le temps est une ressource précieuse qu’on n’arrive jamais à ressaisir une fois qu’il est dilapidé. Mais lorsqu’il est bien géré, il produit de nombreux avantages observables en termes d’efficacité et de productivité au travail.
Henri INGWA LOFINDA   +1 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Une autre Université pour Connaître Autrement (Partie III) Une Université Générative

open access: yesRomanian Economic Journal
humaines, en particulier de la philosophie. Le mérite est évoqué lorsqu’on s’intéresse à la nouvelle mission de l’Université, de plus en plus engagée à intégrer les qualités humaines de la pensée avec les opportunités offertes par la technologie, une ...
Elvira Lussana
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Hakem Listesi 2018

open access: yesÜniversite Araştırmaları Dergisi, 2018
Hakem ...
Üniversite Araştırmaları
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

L’Université qui vient, en ruines et en miettes

open access: yesRevue Internationale Animation, Territoires et Pratiques Socioculturelles
Cet article porte sur l’évolution de l’enseignement supérieur public et privé dans un contexte de rationalisation économique et idéologique qui a mis au pas l’Université française.
Nicolas Oblin
doaj   +1 more source

Le marquis de Pombal et la politique scientifique du Portugal

open access: yesBulletin du Centre de Recherche du Château de Versailles, 2006
The educational reforms carried out by the Marquess of Pombal (1699–1782) in the middle of the eighteenth century are generally considered as one of the critical moments in the genesis of Portugal’s modern science policy.
Henrique Leitão
doaj   +1 more source

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