Results 21 to 30 of about 471,751 (211)
Une autre Université pour Connaître Autrement (Partie III) Une Université Générative
Romanian Economic Journalhumaines, en particulier de la philosophie. Le mérite est évoqué lorsqu’on s’intéresse à la nouvelle mission de l’Université, de plus en plus engagée à intégrer les qualités humaines de la pensée avec les opportunités offertes par la technologie, une ...
Elvira Lussana
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Le négationnisme colonial, de l’Université à la littérature de gare
Cahiers d’histoire, 2006 La réhabilitation de l’action de la France outre-mer, voire l’apologie de la violence coloniale, s’exposent beaucoup plus souvent et ouvertement qu’on ne le croit, dans des publications à prétention « historique » qui vont du témoignage auto-exonérateur ...
Francis Arzalier
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
De la gestion du temps d’études par les apprenants de la propédeutique de l’Université de Kinshasa [PDF]
Mouvements et Enjeux Sociaux, 2023 Le temps est une ressource précieuse qu’on n’arrive jamais à ressaisir une fois qu’il est dilapidé. Mais lorsqu’il est bien géré, il produit de nombreux avantages observables en termes d’efficacité et de productivité au travail.
Henri INGWA LOFINDA +1 more
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source