Results 51 to 60 of about 486,392 (266)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Hitting the Road towards a Greater Digital Destination: Evaluating and Testing DAMS at the University of Houston Libraries

open access: yesInformation Technology and Libraries, 2016
Since 2009, tens of thousands of rare and unique items have been made available online for research through the University of Houston Digital Library.
Annie Wu   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

University Libraries and Social Media - The Case of the Postmodern Library, Kenyatta University

open access: yes027.7 Zeitschrift für Bibliothekskultur, 2013
DOI: 10.12685/027.7-1-1-14Die Post Modern Library (PML) ist die Universitätsbibliothek der Kenyatta University in Nairobi. Die Bibliothek bietet uneingeschränkten drahtlosen Internetzugang sowie weitere Dienstleistungen an, die die üblichen Möglichkeiten kenianischer Bibliotheken bei Weitem übersteigen.
Njoroge, George Gitau   +1 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Strategi Pengelolaan Unit Penunjang Universitas Perpustakaan Universitas Gadjah Mada 'Yogyakarta (Strategy of Management of Gadjah Mada University Libraries Yogyakarta)

open access: yesBerkala Ilmu Perpustakaan dan Informasi, 2015
Gadjah Mada University Libraries are expected to provide a better fast, easy and efficient service. In the past few years, there were some changes at the Gadjah Mada University Libraries; moreover Gadjah Mada University is stated to be a research ...
Wahyu Supriyanto   +2 more
doaj   +1 more source

People-First Promotion: Rallying Library Workers during COVID-19 and Beyond [PDF]

open access: yesMarketing Libraries Journal, 2021
COVID-19 forced workers around the world to face the realities of closed buildings, precarious employment situations, and challenges to their well-being.
Kelly, Katy   +3 more
doaj  

University Libraries and University Research

open access: yesCollege & Research Libraries, 1972
Made available in DSpace on 2013-01-30T21:49:22Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) crl_33_06_447_opt.pdf: 1172552 bytes, checksum: bc465ff83410160bda826ef62cea71ab (MD5) Previous issue date: 1972-11 ; published or submitted for ...
Redmond, Donald A.   +2 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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