Cu-catalyzed Asymmetric Alkylation for Chiral Unnatural α-Substituted α-Amino Acids of Phallotoxins [PDF]
, 2023 Asymmetric alkylation is one of the most important methods for synthesizing chiral unnatural α-substituted α-amino acids. Herein, We reported an asymmetric alkylation of tert-butyl glycinate Schiff base catalyzed by copper/(4S,2R)-tBu-Phosferrox ...
Yang, Wang +6 more
core +2 more sources
Electrochemical Synthesis of Unnatural Amino Acids Embedding 5- and 6-Membered Heteroaromatics [PDF]
, 2023 Using a commercially available potentiostat, the electrochemical synthesis of unnatural amino acids bearing heteroaromatics on the lateral chain has been accomplished.
Paolo, Ronchi +5 more
core +2 more sources
Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2010 New tools are needed to study the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), to facilitate new drug discovery and vaccine development.
Feng Wang +4 more
doaj +1 more source
Light Regulation of Enzyme Allostery through Photo-responsive Unnatural Amino Acids [PDF]
Cell Chemical Biology, 2019 Astrid Bruckmann +2 more
exaly +2 more sources
Asymmetric Synthesis of Unnatural α-Amino Acids through Photoredox-Mediated C–O Bond Activation of Aliphatic Alcohols [PDF]
, 2023 An efficient protocol for the asymmetric synthesis of unnatural amino acids is realized through photoredox-mediated C–O bond activation of oxalate esters derived from aliphatic alcohols as the radical precursors.
Andrey, Shatskiy +7 more
core +2 more sources
Synthesis of Isothiocyanates Using DMT/NMM/TsO− as a New Desulfurization Reagent
Molecules, 2021 Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with ...
Łukasz Janczewski +2 more
doaj +1 more source
Stereoselective Synthesis of Unnatural α-Amino Acids through Photoredox Catalysis [PDF]
, 2020 A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural α-amino acids.
Andrey, Shatskiy +5 more
core +2 more sources
Results in Chemistry, 2023 Protease specificity depends on the three-dimensional structure and sequence of the protease, and each protease plays a different role. Chymotrypsin and subtilisin have similar specificity for recognizing aromatic and hydrophobic amino acid residues ...
Yuuki Yamawaki, Tamaki Kato
doaj +1 more source
Photoinduced β-fragmentation of aliphatic alcohol derivatives for forging C–C bonds
Nature Communications, 2022 Transformations of alcohols, which are ubiquitous in chemistry and are native functionalities in many natural products and bioactive molecules, are cornerstones of organic synthesis.
Yiman Gao +6 more
doaj +1 more source
Electrochemical Synthesis of Unnatural Amino Acids Embedding 5- and 6‑Membered Heteroaromatics [PDF]
ACS OmegaElena Bombonato +6 more
doaj +2 more sources