Results 21 to 30 of about 33,743 (304)
NMR Studies of Large Protein Dynamics Using Unnatural Amino Acids
Chinese Journal of Magnetic Resonance, 2021 Nuclear magnetic resonance (NMR) is a major method used to study protein structure at atomic resolution. Besides presenting the high-resolution structure, NMR facilitates studies on protein dynamics near physiological conditions that are intimately ...
Chao-wei SHI, Pan SHI, Chang-lin TIAN
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Metabolism of amino acid amides in Pseudomonas putida ATCC 12633 [PDF]
, 1993 The metabolism of the natural amino acid L-valine, the unnatural amino acids D-valine, and D-, L-phenylglycine (D-, L-PG), and the unnatural amino acid amides D-, L-phenylglycine amide (D, L-PG-NH2) and L-valine amide (L-Val-NH2) was studied in ...
Croes, L.M., +4 more
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Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst
STAR Protocols, 2023 Summary: Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quantitative technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcohols as alkylating agents and
Beatriz Saavedra +3 more
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Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]
, 2012 G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder +5 more
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Frontiers in Chemistry, 2019 Unnatural amino acids have tremendously expanded the folding possibilities of peptides and peptide mimics. While α,α-disubstituted and β-amino acids are widely studied, γ-derivatives have been less exploited.
Francesco Oliva +5 more
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Biochemistry and Biophysics Reports, 2019 Many biophysical techniques that are available to study the structure, function and dynamics of cellular constituents require modification of the target molecules.
Leonhard Jakob +2 more
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Novel Crown Ether Amino Acids as Fluorescent Reporters for Metal Ions
Molecules, 2023 Unnatural amino acids with enhanced properties, such as increased complexing ability and luminescence, are considered to be highly attractive building blocks for bioinspired frameworks, such as probes for biomolecule dynamics, sensitive fluorescent ...
Patrícia M. R. Batista +3 more
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Protecting‐Group‐Free Amidation of Amino Acids using Lewis Acid Catalysts [PDF]
, 2018 Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids.
Badland, M +5 more
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Expanding the genetic code of Mus musculus
Nature Communications, 2017 Expanding the genetic code with unnatural amino acids in model organisms is a powerful tool for investigatingin vivocellular proteins and processes. Here the authors re-engineer the amber stop codon in laboratory mice to allow site-specific incorporation
Songmi Han +5 more
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Antimicrobial Activity of Amino Acid Analogues and Their Derivatives
Proceedings, 2017 Libraries of compounds containing unnatural amino acids or amino acid analogues were prepared from inexpensive substrates using sustainable processes [1–3]. [...]
Dácil Hernández +4 more
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