Results 181 to 190 of about 124,046 (257)

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

Integrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng, Lu Wang, Runhan Li, Wenkai Lai, Chongkui Sun, Jianguo Cui, Bicheng Zhu, Jiang Zhang   +7 more
wiley   +1 more source

What's in a name? Metabolite identification: challenges and pitfalls in untargeted metabolomics. [PDF]

Metabolomics
Theodoridis G, Fiehn O, Holčapek M, Goodacre R, Raftery D, Plumb R, Ebbels TMD, Witting M, Gika H, Wilson ID.   +9 more
europepmc   +1 more source

Mind(the)Plant: An expandable multimodal facility for the integrated characterization of plant behaviour

Methods in Ecology and Evolution, EarlyView.
Abstract Understanding plant behaviour requires the integration of multiple phenotypic and physiological signals measured over time under controlled conditions. However, different plant signals are typically studied using separate experimental setups, limiting temporal alignment and integrative analyses.
Valentina Simonetti, Bianca Bonato, Silvia Guerra, Sara Avesani, Luca Semenzato, Maria Bulgheroni, Gabriela Gjinaj, Laura Ravazzolo, Marco Dadda, Umberto Castiello   +9 more
wiley   +1 more source

Decoding Biothreats With FT-ICR-MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics. [PDF]

J Mass Spectrom
Romão MI, Gomes I, Antunes W, Novak P, Sousa Silva M, Cordeiro C.   +5 more
europepmc   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Genotype-Dependent Phenylpropanoid Pathway Specialization in Prunus avium Fruits and Leaves Revealed by Untargeted Metabolomics. [PDF]

Physiol Plant
Ardagna G, Gambini S, Bulgarini A, Negri S, Bianconi M, Di Carlo F, Ceoldo S, Guzzo F, Commisso M.   +8 more
europepmc   +1 more source

Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study. [PDF]

Int J Mol Sci
Aslan C, Kaplan O, Yalçın N, Fidan BB, Çelebier M, Ünal D, Allegaert K.   +6 more
europepmc   +1 more source

Multimodal Exploratory Analysis of Persistent Diabetic Macular Edema: Integrating Aqueous Humour Metabolomics, Clinical and OCT Features

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Purpose This exploratory study integrates aqueous humour metabolomic data with clinical and imaging features to examine candidate biomarkers and characterize multimodal patterns associated with persistent diabetic macular edema (pDME). Methods In this prospective cohort study, DME patients were treated with monthly anti‐VEGF injections over 3 ...
Yunhan Tao, Huimin Yu, Yunxi Ma, Mingzhu Yuan, Guochong Chen, Jun Liu, Xi Chen, Xufang Sun   +7 more
wiley   +1 more source

Serum 1H NMR-Based Untargeted Metabolomics for Noninvasive Early Detection of Breast Cancer. [PDF]

J Proteome Res
Ali A, Tengku Din TADAA, Maulidiani M, Arafat HM, Abdul Rahman WFW, Mazuwin Yahya M, Kadiman S, Ramli RAB, Wan Azman WN.   +8 more
europepmc   +1 more source

Oral Butyrate Reduces Progression of Kidney Damage in an L‐NAME‐Induced Diabetic Kidney Disease Mouse Model

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function.
Maria Novella Nicese, Angela Koudijs, Reshma Lalai, Cristina Avramut, Rico J. E. Derks, Elena Sánchez‐López, Martin Giera, Amanda C. M. Pronk, Artemiy Kovynev, Sander Kooijman, Patrick C. N. Rensen, Roel Bijkerk, Bernard M. van den Berg, Joris I. Rotmans   +13 more
wiley   +1 more source