Results 191 to 200 of about 124,046 (257)

Integrated Spatial and Bulk Untargeted Metabolomics Characterize Location- and Histology-Associated Metabolic Heterogeneity in Colorectal Cancer. [PDF]

J Proteome Res
Wang J, Gao J, Liu J, Hu D, Zhan Y.
europepmc   +1 more source

Effects of 6‐OHDA‐Mediated Chemical Denervation of Sympathetic Axons in Inguinal Subcutaneous White Adipose Tissue

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims White adipose tissue (WAT) innervation by sensory and sympathetic axons contributes to tissue functions, but the consequences of selectively disrupting sympathetic input to WAT remain incompletely defined. Materials and Methods We utilised 6‐hydroxydopamine (6‐OHDA) as a validated approach to achieve bilateral sympathetic denervation of ...
Gilian Gunsch, Gargi Mishra, Magdalena Blaszkiewicz, Erica de Sousa, Jake W. Willows, Katharine W. Alltop, Annemarie Towle, Shawn Collins, Andre Khalil, Isabel F. Snodgrass, Lara Agha, Kiran Prakash, Rashmika Maganuru, Sugasini Dhavamani, John W. Newman, Kristy L. Townsend   +15 more
wiley   +1 more source

Ordering molecular diversity in untargeted metabolomics via molecular community networking. [PDF]

Cell Rep Methods
Coler EA, Melnik A, Lotfi A, Moradi D, Ahiadu B, Portal Gomes PW, Patan A, Charron-Lamoureux V, Dorrestein PC, Barnes S, Boginski V, Semenov A, Aksenov AA.   +12 more
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Untargeted Metabolomics Analysis Reveals Potential Metabolic Targets in Gemcitabine-Treated Pancreatic Cancer Cells. [PDF]

Metabolites
Tiwari AP, Rushing BR, Silva L, Sumner SJ, Mukherjee P.   +4 more
europepmc   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

Investigation of the Mechanism of Total Flavonoids From Chuju in Mitigating Cerebral Ischemia-Reperfusion Injury in Rats Using Untargeted Metabolomics. [PDF]

Food Sci Nutr
Zhang G, Zhang Z, Wang C, Shi G, Zhao M, Wu X, Yuan X, Yu H.   +7 more
europepmc   +1 more source

Four Haylages, One Metabonome: Defining Diet Driven Metabolic Shifts in Ponies

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Haylage is widely fed to all categories of stabled horses across Europe and New Zealand. Haylage can vary from high energy nutrient dense forage to low energy highly fibrous fodder, yet little is known about the impact different haylages have on metabolism in horses.
Meriel Moore‐Colyer, Pat Harris, Simon Daniels   +2 more
wiley   +1 more source

Evaluation of FASP for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Urine Samples. [PDF]

J Proteome Res
Mousa MK, Carvalho LB, Giddey AD, Figueiredo A, Al-Hroub H, Semreen MH, Uddin M, Santos HM, Soares NC.   +8 more
europepmc   +1 more source

eCOMET: an R package for evaluating metabolic diversity and enrichment from LC‐MS/MS data to test ecological hypotheses from individuals to ecosystems

New Phytologist, EarlyView.
Overview of eCOMET workflows. Summary Methods in metabolomics have grown exponentially in recent years, providing new insight into the ecological function and evolutionary impact of diverse plant metabolites. Metabolomics requires a command of numerous tools, the outputs of which are typically integrated through in‐house custom code that presents a ...
Min‐Soo Choi, Dale L. Forrister, Guillaume J. Dury, Kyo Bin Kang, Brian E. Sedio, Youngsung Joo   +5 more
wiley   +1 more source