Results 1 to 10 of about 128,122 (96)
How is polyadenylation restricted to 3'-untranslated regions? [PDF]
Yeast, 2023 Polyadenylation occurs at numerous sites within 3’ untranslated regions (3’ UTRs) but rarely within coding regions. How does Pol II travel through long coding regions without generating poly(A) sites, yet then permits promiscuous polyadenylation once it reaches the 3’ UTR?
Struhl K.
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Evidence for widespread translation of 5' untranslated regions. [PDF]
Nucleic Acids ResAbstract Ribosome profiling experiments support the translation of a range of novel human open reading frames. By contrast, most peptides from large-scale proteomics experiments derive from just one source, 5′ untranslated regions. Across the human genome we find evidence for 192 translated upstream regions, most of which would produce ...
Rodriguez JM +5 more
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The Untranslated Regions of mRNAs in Cancer. [PDF]
Trends Cancer, 2019 The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer ...
Schuster SL, Hsieh AC.
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Translating the Untranslated Region [PDF]
The Journal of Immunology, 2015 Abstract Gene expression programs undergo constant regulation to quickly adjust to environmental stimuli that alter the physiological status of the cell, like cellular stress or infection. Gene expression is tightly regulated by multilayered regulatory elements acting in both cis and trans.
Johannes, Schwerk, Ram, Savan
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Genetic variants in mRNA untranslated regions [PDF]
WIREs RNA, 2018 Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants associated with complex disease risk and regulating quantitative traits, thus exploiting an unprecedented high‐resolution genetic characterization of the human genome. A small fraction (3.7%) of the identified associations is located in untranslated regions (UTRs), and the
Steri M, Idda ML, Whalen MB, Orru' V
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Regulatory 3′ Untranslated Regions of Bacterial mRNAs [PDF]
Frontiers in Microbiology, 2017 The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements.
Ren, Gai-Xian +2 more
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Dom34 Rescues Ribosomes in 3′ Untranslated Regions [PDF]
Cell, 2014 Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here, we extend ribosome profiling methodology to reveal a high-resolution molecular characterization
Guydosh, Nicholas R., Green, Rachel
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The ODC 3′-Untranslated Region and 5′-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis [PDF]
Medical Sciences, 2017 It has been hypothesized that both the 3′-untranslated region (3′UTR) and the 5′-untranslated region (5′UTR) of the ornithine decarboxylase (ODC) mRNA influence the expression of the ODC protein. Here, we use luciferase expression constructs to examine the influence of both UTRs in keratinocyte derived cell lines. The ODC 5′UTR or 3′UTR was cloned into
Shannon L. Nowotarski, Lisa M. Shantz
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Expression of distinct RNAs from 3′ untranslated regions [PDF]
Nucleic Acids Research, 2010 The 3' untranslated regions (3'UTRs) of eukaryotic genes regulate mRNA stability, localization and translation. Here, we present evidence that large numbers of 3'UTRs in human, mouse and fly are also expressed separately from the associated protein-coding sequences to which they are normally linked, likely by post-transcriptional cleavage.
T. Mercer +12 more
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Massively parallel functional annotation of 3′ untranslated regions [PDF]
Nature Biotechnology, 2014 Functional characterization of noncoding sequences is crucial for understanding the human genome and learning how genetic variation contributes to disease. 3' untranslated regions (UTRs) are an important class of noncoding sequences, but their functions remain largely uncharacterized.
Zhao, Wenxue +5 more
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