Results 91 to 100 of about 36,901 (236)

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

, 2019
Aim In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC)
Bohnert, B.N., Sophie Daiminger, Wörn, Matthias, Daiminger, S., Haerteis, Silke, Artunc, Ferruh, Schneider, Jonas C., Batbouta, Firas, Staudner, T., Sure, Florian, Ferruh Artunc, Essigke, Daniel, Kanse, S., Haerteis, S., Christoph Korbmacher, Kanse, Sandip, Ilyaskin, A.V., Batbouta, F., Ilyaskin, Alexandr V., Wörn, M., Florian Sure, Tobias Staudner, Matthias Wörn, Jonas C. Schneider, Essigke, D., Silke Haerteis, Bohnert, Bernhard N., Korbmacher, C., Staudner, Tobias, Korbmacher, Christoph, Sure, F., Janessa, A., Bernhard N. Bohnert, Firas Batbouta, Janessa, Andrea, Daiminger, Sophie, Daniel Essigke, Sandip Kanse, Andrea Janessa, Artunc, F., Schneider, J.C., Alexandr V. Ilyaskin   +41 more
core   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source

uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation

, 2012
Myeloid-derived suppressor cells (MDSC) have been shown to play a critical role in tumor-induced immunosuppression, in many mouse and human cancers. The aim of this study was to show that MDSC accumulation is tumor burden-dependent, and to investigate ...
Ilkovitch, Dan, Carrio, Roberto, Lopez, Diana M   +2 more
core   +2 more sources

Unidade de Pronto Atendimento e Atenção Primária à Saúde: uma integração possível [PDF]

Saúde em Debate
RESUMO Este estudo teve como objetivo analisar a complementariedade da atenção e os processos de trabalho entre a Unidade de Pronto Atendimento (UPA) e a Atenção Primária à Saúde (APS) em um município de médio porte no estado do Rio de Janeiro, enfocando
Romero Chartuni Bandeira, Ronaldo Rocha Bastos, Estela Marcia Saraiva Campos, Gisele O’Dwyer   +3 more
doaj   +1 more source

Effect of TNF-α on uPA and uPA receptor expressionin human gingival fibroblasts

International Journal of Oral-Medical Sciences, 2003
Tumor necrotizing factor-alpha (TNF-α) is thought to be an important inflammatory cytokine in the progression of periodontitis. Plasminogen activator (PA) /plasmin cascade plays an important role in the inflammatory process through the activation of metalloprotease.
Mizuguchi, Toshiyuki, Abiko, Yoshimitsu
openaire   +2 more sources

Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 5, Page 799-809, November 2026.
Abstract Objectives The experience of childhood stressful or adverse life events is believed to imprint on immunological pathways and, therefore, might have lasting effects on inflammatory bowel disease (IBD) development. This study aimed to examine the association between experiences of early‐life adverse events and later IBD risk. Methods We followed
Ida Sigvardsson, Ketil Størdal, Henrik Imberg, Elisabeth Fernell, Christopher Gillberg, Johnny Ludvigsson, Karl Mårild   +6 more
wiley   +1 more source

A Cross Talk between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain

, 2017
Urokinase-type plasminogen activator (uPA) is a serine proteinase that, upon binding to its receptor (uPAR), catalyzes the conversion of plasminogen into plasmin on the cell surface.
Manuel Yepes, Ariel Diaz, Paola Merino, Luis Guillermo Manrique, Juan Pablo Ospina, Lihong Cheng, Fang Wu, Valerie Jeanneret   +7 more
core   +1 more source

Tradisi Mangupa Upa Pangaranto Masyarakat Batak Toba di Dusun Gunung Bosar, Bandar Manik – Pematang Sidamanik [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui proses pelaksanaan; tujuan diadakankannya; keluarga yang berperan serta dan makna dan symbol di balik kelengkapan yang dipergunakan dalam tradisi mangupa upa pangaranto.
Syarifa Hanim, Puspitawati Puspitawati
core   +1 more source

Urokinase-type plasminogen activator deficiency enhances CD8+ T cell infiltration and anti-PD-1 therapy efficacy in prostate cancer

Frontiers in Immunology
IntroductionUrokinase-type plasminogen activator (uPA) is upregulated in prostate cancer, but its comprehensive impact on the immune microenvironment and the underlying mechanisms remains to be fully elucidated.MethodsuPA expression was analyzed in ...
Xiaoyi Li, Xiao Zhang, Xing Fu, Hong Wu, Xinyu Ye, Xinyu Ye, Xin Huang, Yuhao Cui, Chao-Nan Qian, Yi Lu, Yi Lu, Jian Zhang, Jian Zhang, Jian Zhang   +13 more
doaj   +1 more source

Online Crowdfunding Campaigns for People Living With ALS Demonstrate Financial Burden and Unmet Needs

Muscle &Nerve, Volume 74, Issue 5, Page 1415-1420, November 2026.
ABSTRACT Introduction/Aims People living with amyotrophic lateral sclerosis (ALS; pALS) have extensive care needs, from wheelchairs to feeding tubes to caregiving support. The financial impact of these needs on pALS and their caregivers (cALS) has not been fully explored.
Astrid Grouls, Peter A. Ubel, Minh Nguyen, Nikhita Pathapati, Steven Doerstling, Caroline E. Sloan   +5 more
wiley   +1 more source