Results 41 to 50 of about 36,901 (236)
Neuroprotection by urokinase plasminogen activator in the hippocampus
Neurobiology of Disease, 2012 Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences
Eunsil Cho +9 more
doaj +1 more source
Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis. [PDF]
PLoS ONE, 2015 Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new ...
Liliana Endo-Munoz +8 more
doaj +1 more source
Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy
Advanced Robotics Research, EarlyView.This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang +11 more
wiley +1 more source
Summary of effects of uPA-binding aptamers on pro-uPA and uPA functions.
, 2015 Summary of effects of uPA-binding aptamers on pro-uPA and uPA functions.
Kenneth A. Bøtkjær (707933) +9 more
core +1 more source
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
core +1 more source
AI as a reflection partner in UX strategy
i-comArtificial Intelligence (AI) is typically considered an efficiency tool in user experience (UX). Far less attention is paid to its potential to structure reflection.
Gronwald Franziska, Rohles Björn
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2011 Macrophages within the tumor microenvironment promote angiogenesis, extracellular matrix breakdown, and tumor cell migration, invasion, and metastasis. Activation of the urokinase plasminogen activator (uPA) and its receptor (uPAR) axis promotes prostate
Jian Zhang +4 more
doaj +1 more source
Heliyon, 2022 Ulipristal acetate (UPA), a selective progesterone receptor modulator, is used for the treatment of uterine fibroids and selectively inhibits the proliferation and inflammation of leiomyoma cells.
Ranka Kanda +8 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source
Overview of uPA aptamer-mediated effects on uPA functions.
, 2015 (A) The ATF-binding aptamer (upanap-12, blue) binds to a composite site in the kringle and growth factor domain. The domain organization of pro-uPA as well as the size and position of the aptamer in the complex allows it to interfere with plasmin ...
Kenneth A. Bøtkjær (707933) +9 more
core +1 more source