Results 171 to 180 of about 14,530 (214)

Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells

Cancers, 2022
The 3′ untranslated region (3′UTR) of the urokinase (uPA) receptor (uPAR) mRNA can act as a competitive endogenous RNA (ceRNA) in acute myeloid leukaemia (AML) cells, promoting the expression of pro-tumoral targets, including uPAR.
Carmine Selleri, Valentina Giudice, Mariaevelina Alfieri   +2 more
exaly   +3 more sources

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Regulation of Cell Signalling by uPAR

Nature Reviews Molecular Cell Biology, 2010
Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many ...
Harvey W Smith
exaly   +3 more sources

Tumor-Associated Soluble uPAR-Directed Endothelial Cell Motility and Tumor Angiogenesis [PDF]

Oncogenesis, 2013
The expression of urokinase-type plasminogen activator (uPA) receptor (uPAR) correlates with the malignant phenotype of various cancers. The soluble form of uPAR (s-uPAR) is present in the circulation of cancer patients, but the role of s-uPAR in ...
J S Rao
exaly   +3 more sources

Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners

Drug Discovery Today, 2021
Urokinase-type plasminogen activator receptor (uPAR) mediates a multitude of biological activities, has key roles in several clinical indications, including malignancies and inflammation, and, thus, has attracted intensive research over the past few decades.
Cai Yuan, Zhanzhi Guo, Shujuan Yu, Longguang Jiang, Mingdong Huang   +4 more
openaire   +2 more sources

uPAR: A Versatile Signalling Orchestrator

Nature Reviews Molecular Cell Biology, 2002
The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a ...
Peter Carmeliet, Francesco Blasi
exaly   +3 more sources

uPAR in angiogenesis regulation

Blood, 2011
In this issue of Blood , Brunner and colleagues demonstrate that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in ...
openaire   +2 more sources

Targeting uPA/uPAR in prostate cancer

Cancer Treatment Reviews, 2007
Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases).
Y, Li, P J, Cozzi
openaire   +2 more sources

uPA and uPAR in fibrinolysis, immunity and pathology

Trends in Immunology, 2004
Abstract The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity.
Anna, Mondino, Francesco, Blasi
openaire   +2 more sources