Emerging roles of haemostatic proteins as markers of disease progression and prognosis in breast cancer. [PDF]
Explor Target Antitumor TherIzuegbuna OO.
europepmc +1 more source
Interferon alpha-induced uPAR expression on monocytes as a potential source of increased soluble uPAR in patients with SLE at high risk of developing organ damage. [PDF]
Clin Exp MedWirestam L +6 more
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[Retracted] uPAR and cathepsin B knockdown inhibits radiation‑induced PKC integrated integrin signaling to the cytoskeleton of glioma‑initiating cells. [PDF]
Int J OncolAlapati K +4 more
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Molecular Imaging in Pancreatic Cancer: Current Applications and Future Perspectives. [PDF]
Pharmaceuticals (Basel)Liu Y, Lan K, Sun Z, Huang W.
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Application of metal-based nanoparticles in targeted drug delivery to breast cancer stem cells. [PDF]
Discov NanoGholizadeh Z, Yousefnia S.
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Regulation of cell signalling by uPAR
Nature Reviews Molecular Cell Biology, 2010Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many ...
Harvey W Smith
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Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners
Drug Discovery Today, 2021Urokinase-type plasminogen activator receptor (uPAR) mediates a multitude of biological activities, has key roles in several clinical indications, including malignancies and inflammation, and, thus, has attracted intensive research over the past few decades.
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uPAR: a versatile signalling orchestrator
Nature Reviews Molecular Cell Biology, 2002The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a ...
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Targeting uPA/uPAR in prostate cancer
Cancer Treatment Reviews, 2007Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases).
Y, Li, P J, Cozzi
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