Results 181 to 190 of about 14,076 (220)
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uPAR in angiogenesis regulation
Blood, 2011In this issue of Blood , Brunner and colleagues demonstrate that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in ...
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uPA and uPAR in fibrinolysis, immunity and pathology
Trends in Immunology, 2004Abstract The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity.
Anna, Mondino, Francesco, Blasi
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Thrombosis and Haemostasis, 2013
doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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Tumor-associated soluble uPAR-directed endothelial cell motility and tumor angiogenesis [PDF]
Oncogenesis, 2013 The expression of urokinase-type plasminogen activator (uPA) receptor (uPAR) correlates with the malignant phenotype of various cancers. The soluble form of uPAR (s-uPAR) is present in the circulation of cancer patients, but the role of s-uPAR in ...
M. Gujrati (7947515) +2 more
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uPAR (CD87) as a Biocompatibility Marker of Dialysis Membrane
Blood Purification, 2006<i>Background/Aims:</i> Hemodialysis (HD) therapy may lead to functional changes in patient leukocytes. For example, the upregulation of inflammatory cytokines, such as IL-1β and TNFα, has been well characterized. However, these findings do not explain the entire response of leukocytes in HD.
Takayuki, Sohka +12 more
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Role of uPA/uPAR in the Modulation of Angiogenesis
2013Blood vessels connect all districts of the body and allow blood oxygen and nutrients to reach every cell in the organism. Dysregulation of blood vessel formation or functionality is the origin of a large number of diseases. During new vessel formation, endothelial cells degrade their basement membrane, migrate into the interstitial matrix and ...
MONTUORI, NUNZIA, P. Ragno
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Structure and ligand interactions of the urokinase receptor (uPAR)
Frontiers in Bioscience, 2008The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA.
Kjærgaard, Magnus +4 more
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uPAR and Proteases in Mobilization of Hematopoietic Stem Cells
2008The specific cell-surface receptor for the urokinase-type plasminogen activator (uPA) was identified in 1985; since then, a large body of evidence showed that urokinase-type plasminogen activator receptor (uPAR) was not only the receptor for a proteolytic enzyme but also a multifunctional signaling molecule capable of various interactions and ...
RAGNO, Pia, FRANCESCO BLASI
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Measuring uPAR Dynamics in Live Cells
2008Urokinase-type plasminogen activator receptor (uPAR) is a key component of the urokinase plasminogen activation (uPA) system, which plays important roles in physiological processes as well as in tumor invasion and metastasis. Besides uPAR’s well-established role in the regulation of pericellular proteolysis, a large body of evidences suggests that ...
Moreno Zamai +2 more
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Development of Cyclic Peptide‐Based Radiotracers for uPAR
ChemMedChemAbstractThe urokinase plasminogen activator (uPA) system has garnered attention as a promising biomarker, with the uPA receptor (uPAR) playing a central role in system regulation and demonstrating strong associations with tumorigenicity, invasion, and metastasis.
Xingkai Wang +9 more
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