Results 41 to 50 of about 240,373 (307)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Success and Failure in Upper Secondary Education

Studia paedagogica, 2023
                 
Hlaďo, Petr, Novotný, Petr, Schuchart, Claudia   +2 more
openaire   +1 more source

DIDACTIC ASPECTS OF UPPER SECONDARY AND UNIVERSITY EDUCATION FUNDAMENTALIZATION [PDF]

Science and Education, 2017
Scientists consider fundamentalization as not only a necessary process for education upgrading but also as an im-portant didactic issue. Methodologically designed educational process provides a harmonious combination of both general and specialized knowledge.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Examining the Dynamic Nature of Pupils’ Educational Aspirations: A Longitudinal Mixed-Model Study

Center for Educational Policy Studies Journal
This paper describes the results from a fully integrated longitudinal mixed model study examining the nature of, changes in, and interaction between the upper secondary and higher education aspirations of Croatian pupils.
Boris Jokić, Zrinka Ristić Dedić
doaj   +1 more source

EDUCATION, TECHNOLOGY AND CREATIVE INDUSTRY: A CASE STUDY OF WATTPAD [PDF]

Cadernos de Pesquisa
This article investigates the use of Wattpad application, launched in 2006, in upper secondary Portuguese language classes as an educational tool for reading and writing texts.
Patrícia Margarida Farias Coelho, Marcos Rogério Martins Costa, Rodrigo Otávio dos Santos   +2 more
doaj   +3 more sources

Between ideology and institution: the curriculum of upper‐secondary education [PDF]

Journal of Curriculum Studies, 2009
This study examines apparently similar historical phenomena in 19th‐century Prussia and Switzerland: the establishment of modern foreign languages in the curriculum of upper‐secondary education. Through the course of the 19th century, there appear to have been great transnational European affinities with regard to both the differentiation of the upper ...
openaire   +2 more sources

The implications of school marketisation for students enrolled on introductory programmes in Swedish upper secondary education

, 2017
Sweden has, like most countries, transformed its educational system with the aim of increasing the economic productivity of its citizens. Nowadays, it has one of the world’s most market-oriented school systems, including few hindrances for new free ...
Erixon Arreman, Inger, Erixon Arreman, Inger,, Dovemark, Marianne,   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source