Results 1 to 10 of about 165,169 (375)
Frontiers in Pharmacology, 2023 Background: Methicillin-resistant Staphylococcus aureus (MRSA) has now become a major nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of novel approaches to combat the disease is especially important.
Lvyuan Fan +8 more
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Metabolites, 2017 The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate
Georgios Gkotsos +6 more
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Scientific Reports, 2017 Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1).
Lene Alsøe +15 more
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Photoprotecting Uracil by Coupling with Lossy Nanocavities [PDF]
Journal of Physical Chemistry Letters, 2020 We analyze how the photorelaxation dynamics of a molecule can be controlled by modifying its electromagnetic environment using a nanocavity mode. In particular, we consider the photorelaxation of the RNA nucleobase uracil, which is the natural mechanism ...
S. Felicetti +5 more
semanticscholar +1 more source
Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides
Pharmaceutical Fronts, 2021 Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar ...
Xiao-Han Yuan +4 more
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Uracil in the carbonaceous asteroid (162173) Ryugu
Nature Communications, 2023 The pristine sample from the near-Earth carbonaceous asteroid (162173) Ryugu collected by the Hayabusa2 spacecraft enabled us to analyze the pristine extraterrestrial material without uncontrolled exposure to the Earth’s atmosphere and biosphere.
Y. Oba +31 more
semanticscholar +1 more source
Pharmaceuticals, 2022 A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored.
Samar A. El-Kalyoubi +4 more
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A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals
Life, 2021 We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ...
Qian-Qian Chen, Ze-Run Zhao, Xiao Wang
doaj +1 more source
Clinical pharmacology and therapy, 2022 In clinical practice, 25–30% of the patients treated with fluoropyrimidines experience severe fluoropyrimidine‐related toxicity. Extensively clinically validated DPYD genotyping tests are available to identify patients at risk of severe toxicity due to ...
M. de With +21 more
semanticscholar +1 more source
Electrocatalytic multicomponent assembling of aminouracils, aldehydes and malononitrile: An efficient approach to 7-amino-pyrido[2,3-d]pyrimidine-6-carbonitrile derivatives [PDF]
Journal of the Serbian Chemical Society, 2016 Electrocatalytic multicomponent transformation of 6-aminouracils, aromatic aldehydes and malononitrile in ethanol in an undivided cell in the presence of potassium bromide as an electrolyte leads to 7-amino-pyrido[2,3- d]pyrimidine-6 ...
Kazemi-Rad Reyhaneh +2 more
doaj +1 more source