A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals
Life, 2021 We report a prebiotically relevant solution to the N1-ribosylation of pyrimidine nucleobases, a well-known challenge to the RNA world hypothesis. We found that the presence of metal cations and clay minerals enable the previously unachievable direct ...
Qian-Qian Chen, Ze-Run Zhao, Xiao Wang
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Pharmaceuticals, 2022 A series of quinoline–uracil hybrids (10a–l) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored.
Samar A. El-Kalyoubi +4 more
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Synthesis of Natural Product-Like Tricyclic Higher-Carbon Sugar Nucleosides
Pharmaceutical Fronts, 2021 Because of the structural novelty and interesting biological profiles, the synthesis of higher-carbon sugars has been highly pursued. In this work, we first synthesized a series of structurally novel bis-uracil containing tricyclic higher-carbon sugar ...
Xiao-Han Yuan +4 more
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Electrocatalytic multicomponent assembling of aminouracils, aldehydes and malononitrile: An efficient approach to 7-amino-pyrido[2,3-d]pyrimidine-6-carbonitrile derivatives [PDF]
Journal of the Serbian Chemical Society, 2016 Electrocatalytic multicomponent transformation of 6-aminouracils, aromatic aldehydes and malononitrile in ethanol in an undivided cell in the presence of potassium bromide as an electrolyte leads to 7-amino-pyrido[2,3- d]pyrimidine-6 ...
Kazemi-Rad Reyhaneh +2 more
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Uracil-DNA glycosylases preferentially excise mispaired uracil [PDF]
Biochemical Journal, 1992 We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5′-32P-labelled strand an uracil residue facing, on the complementary strand, guanine (mimicking cytosine deamination) or adenine (mimicking dUTP ...
VERRI A +3 more
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Synthesis, Characterization and Antibacterial activities of Uracil and Uracil–Oxalate Complexes with Cr(III) and Fe(III) [PDF]
Engineering and Technology Journal, 2019 New complexes of the some trivalent transition metal ions of the uracil such as [M(Ura)3Cl3] and mixed ligand metal complexes with uracil and oxalic acid [M(Ura)2(OA)(OH2)Cl].H2O type, where (Ura)=Uracil, (OA= Oxalic acid dihydrate, (M= Cr+3 and Fe+3 ...
Shatha Obaid
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Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. [PDF]
PLoS Genetics, 2012 Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase.
Villő Muha +12 more
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Ultrafast Photo-Ion Probing of the Relaxation Dynamics in 2-Thiouracil
Molecules, 2023 In this work, we investigate the relaxation processes of 2-thiouracil after UV photoexcitation to the S2 state through the use of ultrafast, single-colour, pump-probe UV/UV spectroscopy. We place focus on investigating the appearance and subsequent decay
Matthew Scott Robinson +2 more
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Study of the structures and energetics of LiI-water-uracil anionic complexes
Xi'an Gongcheng Daxue xuebao, 2022 Anion effect and anion-cation correlation mechanism are generally not considered in the interaction between metal ions and bases. Thus the geometric structure and electronic structure of the LiI-water-uracil anionic complexes were studied by density ...
LI Renzhong, XU Xiaoyang, HUANG Jian
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Photo-Induced Coupled Nuclear and Electron Dynamics in the Nucleobase Uracil
Frontiers in Physics, 2021 Photo-initiated processes in molecules often involve complex situations where the induced dynamics is characterized by the interplay of nuclear and electronic degrees of freedom.
Lena Bäuml +4 more
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