Results 1 to 10 of about 76,749 (150)
Synthesis of Dinucleoside Analog of Uracil-Uracil [PDF]
Bulletin of the Chemical Society of Japan, 1973 AbstractDurch Reaktion des Äthoxypyrimidons (I) mit Epichlorhydrin in Gegenwart katalytischer K2CO3‐ Mengen in Dimethylformamid bei 70‐80°C läßt sich das N‐Chlorhydroxypropyl‐derivat (II) darstellen.
Toru Seita +2 more
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Uracil-DNA glycosylases preferentially excise mispaired uracil [PDF]
Biochemical Journal, 1992 We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5′-32P-labelled strand an uracil residue facing, on the complementary strand, guanine (mimicking cytosine deamination) or adenine (mimicking dUTP ...
VERRI A +3 more
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Uracil mustard revisited [PDF]
Cancer, 1999 A patient with diffuse large cell lymphoma who had a complete response lasting 35 years following a 3-day course of uracil mustard stimulated a recall review of patients treated with this oral alkylating agent.Records of patients treated with uracil mustard between 1958 and 1970 were reviewed.
Emina Torlakovic +2 more
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Uracil-Induced Down-Regulation of the Yeast Uracil Permease [PDF]
Journal of Bacteriology, 1999 ABSTRACT In Saccharomyces cerevisiae the FUR4 -encoded uracil permease catalyzes the first step of the pyrimidine salvage pathway. The availability of uracil has a negative regulatory effect upon its own transport.
Karin Séron +3 more
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A study of the valence photoelectron spectrum of uracil and mixed water–uracil clusters
The Journal of Chemical Physics, 2023 The valence ionization of uracil and mixed water–uracil clusters has been studied experimentally and by ab initio calculations. In both measurements, the spectrum onset shows a red shift with respect to the uracil molecule, with the mixed cluster characterized by peculiar features unexplained by the sum of independent contributions of the water or ...
Giuseppe Mattioli +15 more
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A structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs [PDF]
Nucleic Acids Research, 2014 The uracil DNA glycosylase superfamily consists of several distinct families. Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to exhibit glycosylase activity on three mismatched base pairs, T/U, G/U and C/U. Family 1 uracil N-glycosylase (UNG) from E.
Weiguo Cao +8 more
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Structure of the uracil complex ofVaccinia virusuracil DNA glycosylase [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013 Poxvirus uracil DNA glycosylases are the most diverse members of the family I uracil DNA glycosylases (UNGs). The crystal structure of the uracil complex of Vaccinia virus uracil DNA glycosylase (D4) was determined at 2.03 Å resolution. One uracil molecule was located in the active-site pocket in each of the 12 noncrystallographic symmetry-related D4 ...
Debasish Chattopadhyay +3 more
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Structural basis for uracil DNA glycosylase interaction with uracil: NMR study [PDF]
Nucleic Acids Research, 2000 Two dimensional (2D) NMR and molecular dynamics simulations have been used to determine the three dimensional (3D) structure of a hairpin DNA, d-CTA-GAGGATCC-TUTT-GGATCCT (22mer; abbreviated as U2-hairpin), which has uracil at the second position from the 5' end of the tetraloop.
Ghosh, Mahua +3 more
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Dissociative multi-photon ionization of isolated uracil and uracil-adenine complexes [PDF]
International Journal of Mass Spectrometry, 2016 Recent multi-photon ionization (MPI) experiments on uracil revealed a fragment ion at m/z 84 that was proposed as a potential marker for ring opening in the electronically excited neutral molecule. The present MPI measurements on deuterated uracil identify the fragment as C3H4N2O+ (uracil+ less CO), a plausible dissociative ionization product from the ...
Nigel J. Mason +9 more
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Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs [PDF]
Journal of Biological Chemistry, 2013 The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not found in mammalian cells, as the focal enzyme of pyrimidine salvage because all exogenous ...
Radika Soysa +7 more
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