Results 51 to 60 of about 8,610 (171)

New DNA Repair and Demethylation Functions in Uracil DNA Glycosylase Superfamily [PDF]

, 2023
Uracil-DNA glycosylase (UDG) superfamily, which consists of several groups of enzymes that recognize the damaged DNA bases and initiate the base excision repair (BER) pathway, is most important in dealing with DNA deamination and other base modifications.
Chang, Chenyan
core   +1 more source

Targeting uracil-DNA glycosylases for therapeutic outcomes using insights from virus evolution [PDF]

, 2019
Ung-type uracil-DNA glycosylases are frontline defenders of DNA sequence fidelity in bacteria, plants, and animals; Ungs also directly assist both innate and humoral immunity.
Bouhamdan M, Chamberlin M, Friedberg EC, Katz GE, Le Rouzic E, Lindahl T, Lovett PS, Mahler I, Maisch WF, Price AR, Pyles RB, Renos Savva, Rhoades M, Stuart DT, Tomita F, Tomita F, Wang Z, Warner HR, Willetts KE   +18 more
core   +1 more source

USER fusion: a rapid and efficient method for simultaneous fusion and cloning of multiple PCR products [PDF]

, 2007
We present a method that allows simultaneous fusion and cloning of multiple PCR products in a rapid and efficient manner. The procedure is based on the use of PCR primers that contain a single deoxyuridine residue near their 5′ end.
Geu-Flores, Fernando, Halkier, Barbara A., Nielsen, Morten T., Nour-Eldin, Hussam H.   +3 more
core   +2 more sources

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance APOBEC3B (A3B) is overexpressed in multiple tumor types and a major source of mutation by converting DNA cytosines to uracils. A3B-positive tumors are often more heterogenous and result in poor clinical outcomes. We show that a proportion of
A. Serebrenik, G. Starrett, Sterre Leenen, Matthew C. Jarvis, N. Shaban, D. Salamango, H. Nilsen, W. Brown, R. Harris   +8 more
semanticscholar   +1 more source

Inducible and constitutive promoters for genetic systems in Sulfolobus acidocaldarius [PDF]

, 2018
Central to genetic work in any organism are the availability of a range of inducible and constitutive promoters. In this work we studied several promoters for use in the hyperthermophilic archaeon Sulfolobus acidocaldarius. The promoters were tested with
Albers, Sonja-Verena, Berkner, Silvia, Lipps, Georg, Wlodkowski, Alexander   +3 more
core  

Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik [PDF]

, 2017
Defects of N-linked glycosylation represent diseases with multiple organ involvements that are classified as congenital disorders of glycosylation (CDG).
Aebi, Markus, Berger, Eric G., Frank, Christian G., Grubenmann, Claudia E., Hennet, Thierry, Hülsmeier, Andreas J., Matthijs, Gert, Mayatepek, Ertan, Schollen, Els   +8 more
core  

Analysis of the impact of a uracil DNA glycosylase attenuated in AP-DNA binding in maintenance of the genomic integrity in Escherichia coli [PDF]

, 2010
Uracil DNA glycosylase (Ung) initiates the uracil excision repair pathway. We have earlier characterized the Y66W and Y66H mutants of Ung and shown that they are compromised by ∼7- and ∼170-fold, respectively in their uracil excision activities.
Acharya, Acharya, Aravind, Barrett, Blaisdell, Blattner, Caradonna, Cone, Datsenko, Demple, Dianov, Dianov, Domena, Emsley, Fels, Friedberg, Graves, Guillet, Handa, Handa, Handa, Imlay, Kavli, Krokan, Krusong, Lancaster, Lin, Lindahl, Lindahl, Lindahl, Lindahl, Loeb, Lu, Miller, Otterlei, Parikh, Payne, Pope, Putnam, Ravishankar, Reid, Roy, Sambrook, Sanjay Kumar Bharti, Snowden, Sohail, Spek, Srinath, Talpaert-Borle, Umesh Varshney, Van Der Spoel, Venkatesh, Vieira, Warner, Waters, Williams, Yu, Yu   +57 more
core   +2 more sources

Can biowarfare agents be defeated with light? [PDF]

, 2013
Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores,
de Sousa, Marcelo Victor Pires, Ferraresi, Cleber, Hamblin, Michael R, Rineh, Ardeshir, Sharma, Sulbha K, Vatansever, Fatma, Yin, Rui   +6 more
core   +1 more source

Terminal Deoxynucleotidyl Transferase and T7 Exonuclease-Aided Amplification Strategy for Ultrasensitive Detection of Uracil-DNA Glycosylase.

Analytical Chemistry, 2018
As one of the key initiators of the base excision repair process, uracil-DNA glycosylase (UDG) plays an important role in maintaining genomic integrity. It has been found that aberrant expression of UDG is associated with a variety of diseases.
Yichen Du, Yunxi Cui, Xiaoyu Li, Guo-Ying Sun, Yu-Peng Zhang, An-Na Tang, Kwangil Kim, Deming Kong   +7 more
semanticscholar   +1 more source

UV-radiation-induced formation of DNA bipyrimidine photoproducts in Bacillus subtilis endospores and their repair during germination [PDF]

, 2008
The spore photoproduct (SP) is the main DNA lesion after UV-C irradiation, and its repair is crucial for the resistance of spores to UV. The aims of the present study were to assess the formation and repair of bipyrimidine photoproducts in spore DNA of ...
Erko Stackebrandt, Gerda Horneck, Günther Reitz, Jean Cadet, Petra Rettberg, Ralf Moeller, Thierry Douki, Wayne L. Nicholson   +7 more
core   +2 more sources