A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping [PDF]
, 2018 Efficient γ-herpesvirus lytic phase replication requires a virally encoded UNG-type uracil-DNA glycosylase as a structural element of the viral replisome.
Bagneris, Claire +5 more
core +2 more sources
Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine [PDF]
, 2017 Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine genetic information by inducing DNA inter- and intra-strand crosslinks, protein-DNA crosslinks, and chemical alterations to the sugar or base moieties of DNA.
Banda, Douglas M +4 more
core +1 more source
High-fidelity correction of genomic uracil by human mismatch repair activities [PDF]
, 2008 Background Deamination of cytosine to produce uracil is a common and potentially mutagenic lesion in genomic DNA. U•G mismatches occur spontaneously throughout the genome, where they are repaired by factors associated with the base excision repair ...
Bednarski, David W +2 more
core +3 more sources
Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities [PDF]
, 2015 The restriction-modification systems use epigenetic modification to distinguish between self and nonself DNA. A modification enzyme transfers a methyl group to a base in a specific DNA sequence while its cognate restriction enzyme introduces breaks in ...
Fukuyo, Masaki +9 more
core +2 more sources
The Base Excision Repair System of Salmonella enterica serovar Typhimurium Counteracts DNA Damage by Host Nitric Oxide [PDF]
, 2009 Intracellular pathogens must withstand nitric oxide (NO·) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify
AE Suvarnapunya +52 more
core +3 more sources
Specificity and Catalytic Mechanism of DNA Glycosylases in UDG Superfamily [PDF]
, 2014 DNA can be damaged by several kinds of endogenous and exogenous reactive nitrogen species. Under nitosative stress, uracil (U), hypoxanthine (I), xanthine (X) and oxanine (O) are four major deaminated DNA bases derived from cytosine (C), adenine (A) and ...
Xia, Bo
core +1 more source
Adaptive evolution of drug targets in producer and non-producer organisms [PDF]
, 2012 Mycophenolic acid (MPA) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of IMP dehydrogenase (IMPDH). The MPA biosynthetic cluster of P.
Balzarini +40 more
core +1 more source
Use of high throughput sequencing to observe genome dynamics at a single cell level
, 2009 With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced
A. Soldatov +29 more
core +1 more source
Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells [PDF]
, 2010 Background Folate (vitamin B9) is essential for cellular proliferation as it is involved in the biosynthesis of deoxythymidine monophosphate (dTMP) and s-adenosylmethionine (AdoMet).
A Gangjee +51 more
core +3 more sources
Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity [PDF]
, 2017 Repair of uracils in DNA is initiated by uracil DNA glycosylases (UDGs). Family 1 UDGs (Ung) are the most efficient and ubiquitous proteins having an exquisite specificity for uracils in DNA.
Chembazhi, U.V. +6 more
core +1 more source