Results 111 to 120 of about 22,001 (241)

Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium [PDF]

, 2015
Proteins responsible for the integrity of the genome are often used targets in drug therapies against various diseases. The inhibitors of these proteins are also important to study the pathways in genome integrity maintenance. A prominent example is Ugi,
Beáta G. Vértessy, Judit E. Szabó, Judit Tóth, Kinga Nyíri, Paula Dobrotka, Rita Hirmondó, Szilvia Tarjányi   +6 more
core   +1 more source

Minimizing DNA contamination by using UNG-coupled quantitative real-time PCR on degraded DNA samples: application to ancient DNA studies

BioTechniques, 2005
PCR analyses of ancient and degraded DNA suffer from their extreme sensitivity to contamination by modern DNA originating, in particular, from carryover contamination with previously amplified or cloned material.
Mélanie Pruvost, Thierry Grange, Eva-Maria Geigl   +2 more
doaj   +1 more source

Identification of potential cell surface targets in patient‐derived cultures toward photoimmunotherapy of high‐grade serous ovarian cancer

Photochemistry and Photobiology, EarlyView.
Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina, Anish Raju Amara, Rafay Abu, Bryan Q. Spring   +3 more
wiley   +1 more source

Mitogenomes of museum specimens provide new insight into species classification and recently reduced diversity of highly endangered Nomascus gibbons

Integrative Zoology, Volume 20, Issue 3, Page 674-684, May 2025.
Our findings reveal that the western black crested gibbon (Nomascus concolor) did not divide into different subspecies, and the relatively low level of genetic diversity emphasizes the importance of monitoring this indicator for vulnerable wildlife.
Siqiong LIU, Kexin LI, Yuxin ZHENG, Jiayang XUE, Sheng WANG, Song LI, Peng CAO, Feng LIU, Qingyan DAI, Xiaotian FENG, Ruowei YANG, Wanjing PING, Dongdong WU, Pengfei FAN, Qiaomei FU, Zehui CHEN   +15 more
wiley   +1 more source

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases [PDF]

, 2017
Hydroxyl radicals predominantly react with the C8 of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells.
Couvé, Sophie, Ishchenko, Alexander A., Kunz, Christophe, Saparbaev, Murat, Schär, Primo, Talhaoui, Ibtissam   +5 more
core  

Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase. [PDF]

Mol Microbiol, 2023
Buckley RJ, Lou-Hing A, Hanson KM, Ahmed NR, Cooper CDO, Bolt EL.   +5 more
europepmc   +1 more source

Escherichia coli K-12 mutants deficient in uracil-DNA glycosylase [PDF]

, 1978
Bruce K. Duncan, P A Rockstroh, Huber R. Warner   +2 more
openalex   +1 more source

Uracil DNA-glycosylase from HeLa cells: general properties, substrate specificity and effect of uracil analogs [PDF]

, 1981
Hans E. Krokan, Christian Urs Wittwer
openalex   +1 more source

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.

PLoS Biology, 2007
Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells.
Adam J L Cook, Joanna M Raftery, K K Edwin Lau, Andrew Jessup, Reuben S Harris, Shunichi Takeda, Christopher J Jolly   +6 more
doaj   +1 more source

DR0022 from Deinococcus radiodurans is an acid uracil-DNA glycosylase. [PDF]

FEBS J, 2022
Li J, Yang Y, Chang C, Cao W.
europepmc   +1 more source