Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2 [PDF]
, 2017 Human Thymine-DNA Glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily. It excises uracil, thymine and a number of chemical base lesions when mispaired with guanine in double-stranded DNA.
Focke, Frauke +4 more
core
Uracil-DNA Glycosylase Assay by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry Analysis. [PDF]
J Vis Exp, 2022 Chang HL +7 more
europepmc +1 more source
DNA Repair Enzyme Uracil DNA Glycosylase Is Specifically Incorporated into Human Immunodeficiency Virus Type 1 Viral Particles through a Vpr-Independent Mechanism [PDF]
, 1999 Karen Willetts +6 more
openalex +1 more source
Specificity and Catalytic Mechanism of DNA Glycosylases in UDG Superfamily [PDF]
, 2014 DNA can be damaged by several kinds of endogenous and exogenous reactive nitrogen species. Under nitosative stress, uracil (U), hypoxanthine (I), xanthine (X) and oxanine (O) are four major deaminated DNA bases derived from cytosine (C), adenine (A) and ...
Xia, Bo
core +1 more source
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions. [PDF]
DNA Repair (Amst), 2021 Perkins JL, Zhao L.
europepmc +1 more source
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase [PDF]
, 1998 T. Haug +5 more
openalex +1 more source
Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication [PDF]
, 2000 Hilde Nilsen +9 more
openalex +1 more source
NOVEL XANTHINE AND OXANINE DNA GLYCOSYLASE ACTIVITIES IN YEAST AND MAMMALIAN SYSTEMS [PDF]
, 2008 DNA that stores genetic information is frequently damaged in cells. The DNA bases carrying an exocyclic amino group [adenine (A), guanine (G), cytosine (C)] encounter deamination even under physiological conditions.
Dong, Liang
core +1 more source
SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
Cell Reports, 2019 Summary: Telomerase biogenesis is a complex process where several steps remain poorly understood. Single-strand-selective uracil-DNA glycosylase (SMUG1) associates with the DKC1-containing H/ACA ribonucleoprotein complex, which is essential for ...
Penelope Kroustallaki +10 more
doaj
Nature CommunicationsDNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C
Huawei Tong +15 more
doaj +1 more source