Results 181 to 190 of about 24,501 (233)

Inhibition of Uracil DNA Glycosylase Alters Frequency and Spectrum of Action-at-a-Distance Mutations Induced by 8-Oxo-7,8-dihydroguanine

Tetsuya Suzuki, Saho Yoshida, Hiroyuki Kamiya   +2 more
openalex   +2 more sources

What is in a name? Rethinking SMUG1 in genome maintenance. [PDF]

NAR Cancer
Rudolfova N, Skjetne AM, Montaldo NP, Visnes T, Nilsen HL, Michel M.   +5 more
europepmc   +1 more source

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Construction of an Entropy-Driven Dumbbell-Type DNAzyme Assembly Circuit for Lighting Up Uracil-DNA Glycosylase in Living Cells.

Analytical Chemistry, 2022
Sensitive monitoring of intracellular uracil-DNA glycosylase (UDG) in living cells is essential to understanding the DNA repair pathways and discovery of anticancer drugs. Herein, we demonstrate the construction of an entropy-driven dumbbell-type DNAzyme
Qian Zhang, Ran Zhao, Chen-chen Li, Yan Zhang, Chunying Tang, Xiliang Luo, Fei Ma, Chun-yang Zhang   +7 more
semanticscholar   +1 more source

Distance-Based Biosensor for Ultrasensitive Detection of Uracil-DNA Glycosylase Using Membrane Filtration of DNA Hydrogel.

ACS Sensors, 2021
In the deoxyribonucleic acid (DNA) repair pathways, DNA repair enzymes have great significance for genomic integrity. As one important initiator of the base-excision repair pathway, the aberrant activity of uracil-DNA glycosylase (UDG) is closely ...
Chao Jiang, Fangfang Wang, Kexin Zhang, Tiantian Min, Desheng Chen, Y. Wen   +5 more
semanticscholar   +1 more source

Single-Nanoparticle ICP-MS for Sensitive Detection of Uracil-DNA Glycosylase Activity.

Analytical Chemistry, 2021
Single-nanoparticle inductively coupled plasma mass spectrometry (SP-ICP-MS) has demonstrated unique advantages for the detection of biological samples.
Bang-Rui Li, Hao Tang, R. Yu, Jian-hui Jiang   +3 more
semanticscholar   +1 more source

A structure change-induced fluorescent biosensor for uracil-DNA glycosylase activity detection based on the substrate preference of Lambda exonuclease.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2022
As one of the initiating DNA glycosylases in the base excision repair pathway, Uracil-DNA glycosylase (UDG) plays a pivotal role in maintaining genomic integrity.
Jianbo Sun, Changjian Li, Yuqiang Hu, Yawen Ding, Tongbo Wu   +4 more
semanticscholar   +1 more source

Cytosine base editing in cyanobacteria by repressing archaic Type IV uracil-DNA glycosylase.

The Plant Journal, 2022
Base editing enables precise gene editing without requiring donor DNA or double-stranded breaks. To facilitate base editing tools, a uracil DNA glycosylase inhibitor (UGI) was fused to cytidine deaminase-Cas nickase to inhibit uracil DNA glycosylase (UDG)
Mieun Lee, Y. Heo, H. Woo
semanticscholar   +1 more source

Processivity of uracil DNA glycosylase

Mutation Research/DNA Repair, 1993
The purpose of this study was to determine the mechanism by which uracil DNA glycosylase locates uracil residues within double-stranded DNA. Using reaction conditions that contained low salt concentrations, the addition of uracil DNA glycosylase to plasmid DNAs containing multiple, randomly incorporated uracils resulted in the accumulation of form III ...
M, Higley, R S, Lloyd
openaire   +2 more sources

A methodology for ultra-sensitive detection of the sequence-specific DNA or Uracil-DNA glycosylase activity (UDG).

ACS Sensors, 2020
The ultra-sensitive detection of sequence-specific DNA and UDG activity own a high practical significance in clinical diagnostic and biomedical study.
Xiaolong Chen, Yawen Wu, Gaihua Cao, Xianfeng Wang, Zhong Ji, D. Huo, Faliang Xu, Changjun Hou   +7 more
semanticscholar   +1 more source

Uracil-DNA glycosylase activity from Dictyostelium discoideum

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1986
We have isolated and partially characterized a uracil-DNA glycosylase activity from the cellular slime mold, Dictyostelium discoideum. This glycosylase has a broad pH optimum (6.5-8.5) and is fully active in 10 mM EDTA or in 5 mM Mg2+. Its molecular weight by gel filtration is about 55 000.
R B, Guyer, J M, Nonnemaker, R A, Deering   +2 more
openaire   +2 more sources