Results 11 to 20 of about 24,501 (233)

Mismatch uracil DNA glycosylase (Mug) is maintained in the Corynebacterium pseudotuberculosis genome and exhibits affinity for uracil but not other types of damage [PDF]

Genetics and Molecular Biology
The genome of Corynebacterium pseudotuberculosis, etiologic agent of Caseous Lymphadenitis (CLA), was sequenced to comprehend its genetics, pathogenicity, and virulence mechanisms due to its economic importance.
Bruno Carvalho Resende, Cássio Siqueira Souza Cassiano, Diego Lisboa Rios, Thalia Queiroz Ladeira, Vasco Ariston Carvalho Azevedo, Luciana Lara dos Santos, Lucía Valenzuela-Pérez, Gonzalo Cabrera, Carlos Renato Machado, Débora de Oliveira Lopes   +9 more
doaj   +2 more sources

Poxvirus uracil‐DNA glycosylase—An unusual member of the family I uracil‐DNA glycosylases [PDF]

Protein Science, 2016
AbstractUracil‐DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil‐DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA.
Norbert Schormann, Natalia L. Zhukovskaya, Gregory J. Bedwell, Manunya Nuth, Richard E. Gillilan, Peter E. Prevelige, Robert P. Ricciardi, Surajit Banerjee, Debasish Chattopadhyay   +8 more
openalex   +3 more sources

Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening [PDF]

Heliyon
Uracil-DNA glycosylase (UDG) plays a pivotal role in the base repair system. Through bioinformatics, we found that the expression of the UDG enzyme in many cancer cells is increased, and its high expression is not conducive to the prognosis of lung ...
Pansong Zhang, Fangfang He, Xin Chang
doaj   +2 more sources

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance APOBEC3B (A3B) is overexpressed in multiple tumor types and a major source of mutation by converting DNA cytosines to uracils. A3B-positive tumors are often more heterogenous and result in poor clinical outcomes. We show that a proportion of
Serebrenik AA, Starrett GJ, Leenen S, Jarvis MC, Shaban NM, Salamango DJ, Nilsen H, Brown WL, Harris RS.   +8 more
europepmc   +2 more sources

A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer. [PDF]

Chem Sci, 2020
Many cancers have developed resistance to 5-FU, due to removal by the enzyme uracil-DNA glycosylase (UDG), a type of base excision repair enzyme (BER) that can excise uracil and 5-fluorouracil (5-FU) from DNA.
Li G, Henry SA, Liu H, Kang TS, Nao SC, Zhao Y, Wu C, Jin J, Zhang JT, Leung CH, Wai Hong Chan P, Ma DL.   +11 more
europepmc   +2 more sources

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues [PDF]

mSphere, 2023
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair.
Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug   +7 more
doaj   +2 more sources

Silencing Uracil-DNA glycosylase inhibits colorectal cancer progression [PDF]

Cancer Cell International
Dysregulation of repair pathways, specifically the base excision repair (BER) axis, is frequently observed in cancer. This dysfunction is associated with accelerated tumor growth and reduced patient survival, suggesting that BER components may serve as ...
Jing-jing Yang, Li-zhou Shi, Yong-wei Hu, Hua Chen, Qing-hua Wang, Wei Han   +5 more
doaj   +2 more sources

Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil. [PDF]

Nucleic Acids Res, 2019
UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes.
Sarno A, Lundbæk M, Liabakk NB, Aas PA, Mjelle R, Hagen L, Sousa MML, Krokan HE, Kavli B.   +8 more
europepmc   +2 more sources

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

Nature Communications
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C
Huawei Tong, Haoqiang Wang, Xuchen Wang, Nana Liu, Guoling Li, Danni Wu, Yun Li, Ming Jin, Hengbin Li, Yinghui Wei, Tong Li, Yuan Yuan, Linyu Shi, Xuan Yao, Yingsi Zhou, Hui Yang   +15 more
doaj   +2 more sources

Specificity and Efficiency of the Uracil DNA Glycosylase-Mediated Strand Cleavage Surveyed on Large Sequence Libraries. [PDF]

Sci Rep, 2019
Uracil-DNA glycosylase (UDG) is a critical DNA repair enzyme that is well conserved and ubiquitous in nearly all life forms. UDG protects genomic information integrity by catalyzing the excision from DNA of uracil nucleobases resulting from ...
Hölz K, Pavlic A, Lietard J, Somoza MM.
europepmc   +2 more sources