Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement. [PDF]
PLoS Genetics, 2012 Base-excision repair and control of nucleotide pools safe-guard against permanent uracil accumulation in DNA relying on two key enzymes: uracil-DNA glycosylase and dUTPase.
Villő Muha +12 more
doaj +6 more sources
Viruses with U-DNA: New Avenues for Biotechnology [PDF]
Viruses, 2021 Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy +2 more
doaj +5 more sources
Frontiers in Microbiology, 2016 Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes.
Csaba Kerepesi +9 more
doaj +3 more sources
A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase [PDF]
Viruses, 2023 DNA-mimicking proteins encoded by viruses can modulate processes such as innate cellular immunity. An example is Ung-family uracil-DNA glycosylase inhibition, which prevents Ung-mediated degradation via the stoichiometric protein blockade of the Ung DNA ...
Wael Muselmani +5 more
doaj +2 more sources
Uracil-DNA Glycosylase in the Extreme Thermophile Archaeoglobus fulgidus [PDF]
Journal of Biological Chemistry, 2000 Uracil-DNA glycosylase (UDG) is an essential enzyme for maintaining genomic integrity. Here we describe a UDG from the extreme thermophile Archaeoglobus fulgidus. The enzyme is a member of a new class of enzymes found in prokaryotes that is distinct from the UDG enzyme found in Escherichia coli, eukaryotes, and DNA-containing viruses. The A.
Margarita Sandigursky +1 more
openalex +5 more sources
Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening [PDF]
HeliyonUracil-DNA glycosylase (UDG) plays a pivotal role in the base repair system. Through bioinformatics, we found that the expression of the UDG enzyme in many cancer cells is increased, and its high expression is not conducive to the prognosis of lung ...
Pansong Zhang, Fangfang He, Xin Chang
doaj +2 more sources
Programmable DNA pyrimidine base editing via engineered uracil-DNA glycosylase [PDF]
Nature CommunicationsDNA base editing technologies predominantly utilize engineered deaminases, limiting their ability to edit thymine and guanine directly. In this study, we successfully achieve base editing of both cytidine and thymine by leveraging the translesion DNA ...
Zongyi Yi +10 more
doaj +2 more sources
Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase [PDF]
DNA Repair, 2005 To investigate the role of Arginine 276 in the conserved leucine-loop of human uracil-DNA glycosylase (UNG), the effects of six R276 amino acid substitutions (C, E, H, L, W, and Y) on nucleotide flipping and enzyme conformational change were determined using transient and steady state, fluorescence-based, kinetic analysis.
Cheng-Yao Chen +2 more
openalex +3 more sources
Targeted deaminase-free T-to-G and C-to-K base editing in rice by fused human uracil DNA glycosylase variants. [PDF]
Plant Biotechnol JPlant Biotechnology Journal, Volume 23, Issue 4, Page 1257-1259, April 2025.
Wu Y +7 more
europepmc +2 more sources
Uracil DNA glycosylase 2 negatively regulates HIV-1 LTR transcription [PDF]
Retrovirology, 2009 Tupin Audrey +7 more
doaj +2 more sources