Results 191 to 200 of about 24,501 (233)
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Uracil-DNA glycosylase acts by substrate autocatalysis
Nature, 2001In humans, uracil appears in DNA at the rate of several hundred bases per cell each day as a result of misincorporation of deoxyuridine (dU) or deamination of cytosine. Four enzymes that catalyse the hydrolysis of the glycosylic bond of dU in DNA to yield an apyridiminic site as the first step in base excision repair have been identified in the human ...
A R, Dinner, G M, Blackburn, M, Karplus
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Uracil-DNA Glycosylases and DNA Uracil Repair
1989Publisher Summary This chapter reviews the DNA uracil repair and uracil–DNA glycosylases (UDG). The major source of DNA uracil in prokaryotic and eukaryotic cells is transient incorporation of dUMP during replication. This replicative uracil is quickly repaired by UDG, apyramidinic/apurinic (AP) endonucleases, and other enzymes of excision repair ...
N V, Tomilin, O N, Aprelikova
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Uracil-DNA glycosylase activity in chronic lymphoproliferative disorders
Leukemia Research, 1986The activity of uracil-DNA glycosylase, a repair enzyme for the excision of uracil from DNA, was studied in patients with chronic lymphoproliferative disorders and with malignant plasma cell dyscrasias. The biochemical assay was performed on mononuclear cells, isolated by density gradient centrifugation from peripheral blood, from bone marrow or from ...
P, Koistinen, E, Eerola, J A, Vilpo
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Uracil DNA Glycosylase: Insights from a Master Catalyst
Archives of Biochemistry and Biophysics, 2001The recognition and removal of damaged bases in the genome is the province of a highly specialized assemblage of enzymes known as DNA glycosylases. In recent years, structural and mechanistic studies have rapidly moved forward such that in some cases, the high-resolution structures of all stable complexes along the reaction pathway are available.
J T, Stivers, A C, Drohat
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Multiple uracil-DNA glycosylase activities in Deinococcus radiodurans
DNA Repair, 2004The extremely radiation resistant bacterium, Deinococcus radiodurans, contains a spectrum of genes that encode for multiple activities that repair DNA damage. We have cloned and expressed the product of three predicted uracil-DNA glycosylases to determine their biochemical function.
Margarita, Sandigursky +4 more
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Chemical Communications, 2019
A DNA walker powered by endogenous enzymes is constructed. It performs automatic walking in living cells and can detect the uracil-DNA glycosylase activity in situ.
Xiaowen Xu +4 more
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A DNA walker powered by endogenous enzymes is constructed. It performs automatic walking in living cells and can detect the uracil-DNA glycosylase activity in situ.
Xiaowen Xu +4 more
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Uracil-DNA glycosylase activity in human acute leukemia
Leukemia Research, 1987The expression of the DNA excision repair enzyme uracil-DNA glycosylase was investigated in bone marrow and peripheral samples from seven patients with acute lymphoblastic leukemia (ALL), from 17 patients with acute non-lymphocytic leukemia (ANLL), and from one patient with chronic granulocytic leukemia (CGL) in blast crisis.
P, Koistinen, E, Eerola, J A, Vilpo
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Uracil-DNA glycosylase defective mutants of Ustilago maydis
Current Genetics, 1983Uracil-DNA glycosylase activity can be measured in cell-free extracts of Ustilago maydis and in its general properties the enzyme resembles the same glycosylase from other organisms. A rapid assay was used to screen nearly 1,000 clones from cells treated with N-methyl-N'-nitro-N-nitrosoguanidine, and five isolates had
Y, Yamamoto, R, Holliday
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Journal of Chemical Theory and Computation, 2019
Uracil DNA glycosylase catalyzes the N-glycosidic bond cleavage of uracil, thereby initiating the base excision repair mechanism for this DNA lesion.
E. Naydenova +2 more
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Uracil DNA glycosylase catalyzes the N-glycosidic bond cleavage of uracil, thereby initiating the base excision repair mechanism for this DNA lesion.
E. Naydenova +2 more
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Journal of Physical Chemistry B, 2019
Preserving the genomic integrity is a fundamental requirement, primarily achieved by the DNA Repair Proteins through their continuous patrolling on the DNA in search of lesions.
P. Dey, A. Bhattacherjee
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Preserving the genomic integrity is a fundamental requirement, primarily achieved by the DNA Repair Proteins through their continuous patrolling on the DNA in search of lesions.
P. Dey, A. Bhattacherjee
semanticscholar +1 more source