Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
UV resistance of nucleosides -- an experimental approach [PDF]
, 2020 The emergence of life on Earth is a highly discussed but still unsolved question. Current research underlines the importance of environments within close proximity to the Earth's surface as they can solve long-standing problems such as polymerization of nucleotides and phosphorylation of nucleosides.
arxiv +1 more source
Low-energy electron collisions with gas-phase uracil [PDF]
, 2006 We have studied gas-phase collisions between slow electrons and uracil molecules with a view to understanding the resonance structure of the scattering cross section.
McKoy, Vincent, Winstead, Carl
core +1 more source
Identification of the decay pathway of photoexcited nucleobases [PDF]
arXiv, 2022 The identification of the decay pathway of the nucleobase uracil after being photoexcited by ultraviolet (UV) light has been a long standing problem. Various theoretical models have been proposed but yet to be verified. Here we propose an experimental scheme to test the theoretical models by a combination of ultrafast X-ray spectroscopy, X-ray ...
arxiv
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy [PDF]
, 2013 Uracil in DNA is an important cause of mutagenesis. SMUG1 is a uracil DNA glycosylase that removes uracil through base excision repair. SMUG1 also processes radiation induced oxidative base damage as well as 5-fluorouracil incorporated into DNA during
Abdel-Fatah, TMA +9 more
core +1 more source
Magnetic circular dichroism within the Algebraic Diagrammatic Construction scheme of the polarisation propagator up to third order [PDF]
, 2022 We present an implementation of the B term of Magnetic Circular Dichroism within the Algebraic Diagrammatic Construction (ADC) scheme of the polarization propagator and its Intermediate State Representation. As illustrative results, the MCD spectra of the ADC variants ADC(2), ADC(2)-x and ADC(3) of the molecular systems uracil, 2-thiouracil, 4 ...
arxiv +1 more source
Ultraviolet relaxation dynamics in uracil: Time-resolved photoion yield studies using a laser-based thermal desorption source [PDF]
, 2018 Wavelength-dependent measurements of the RNA base uracil, undertaken with nanosecond ultraviolet laser pulses, have previously identified a fragment at m/z = 84 (corresponding to the C3H4N2O+ ion) at excitation wavelengths ≤232 nm.
Bockova, Jana +9 more
core +2 more sources
Water mediated Electron Attachment to Nucleobases: Surface-bound vs Bulk Solvated Electrons [PDF]
, 2019 We have investigated the electron attachment dynamics of uracil in water using accurate wave-function and QM/MM methods. The initial electron attached state is found to be localized on the water and mixing of electronic and nuclear degrees of freedom leads to the transfer of electron from the water to the uracil.
arxiv +1 more source
Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil [PDF]
, 2013 Archaeal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering uracil in template strands, four bases ahead of the primer-template junction. Should the polymerase progress further towards the uracil, for example,
Allan +48 more
core +1 more source
Multiple scattering and electron-uracil collisions at low energies [PDF]
, 2006 Links between two well known methods: methods of zero-range and non-overlapped (muffin-tin) potentials are discussed. Some difficulties of the method of zero-range potentials and its possible elimination are discussed. We argue that such advanced method of ZRP potential can be applied to realistic electron-molecular processes.
arxiv +1 more source