Results 51 to 60 of about 165,169 (375)

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

British Journal of Cancer, 2017
Background:We investigated the predictive value of dihydropyrimidine dehydrogenase (DPD) phenotype, measured as pretreatment serum uracil and dihydrouracil concentrations, for severe as well as fatal fluoropyrimidine-associated toxicity in 550 patients ...
D. Meulendijks, L. Henricks, B. Jacobs, A. Aliev, M. Deenen, N. de Vries, H. Rosing, E. van Werkhoven, A. de Boer, J. Beijnen, C. Mandigers, M. Soesan, A. Cats, J. Schellens   +13 more
semanticscholar   +1 more source

Site selectivity of halogen oxygen bonding in 5- and 6-haloderivatives of uracil [PDF]

, 2019
Seven 5-and 6-halogenated derivatives of uracil or 1-methyluracil (halogen = Cl, Br, I) were studied by single crystal X-ray diffraction. In contrast with pure 5-halouracils, where the presence of N-H…O and C-H…O hydrogen bonds prevents the formation ...
Portalone, Gustavo
core   +1 more source

Excision Repair-Initiated Enzyme-Assisted Bicyclic Cascade Signal Amplification for Ultrasensitive Detection of Uracil-DNA Glycosylase.

Analytical Chemistry, 2017
Uracil-DNA glycosylase (UDG) is an important base excision repair (BER) enzyme responsible for the repair of uracil-induced DNA lesion and the maintenance of genomic integrity, while the aberrant expression of UDG is associated with a variety of cancers.
Li-juan Wang, Ming Ren, Qianyi Zhang, Bo Tang, Chun-yang Zhang   +4 more
semanticscholar   +1 more source

A structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairs [PDF]

Nucleic Acids Research, 2014
The uracil DNA glycosylase superfamily consists of several distinct families. Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to exhibit glycosylase activity on three mismatched base pairs, T/U, G/U and C/U. Family 1 uracil N-glycosylase (UNG) from E.
Weiguo Cao, Sung-Hyun Park, Dong-Hoon Lee, Bo Xia, Hyun-Wook Lee, Yinling Liu, Hunter Balduf, Allyn R. Brice, Brian N. Dominy   +8 more
openaire   +3 more sources

Detection of Genomic Uracil Patterns [PDF]

International Journal of Molecular Sciences, 2021
The appearance of uracil in the deoxyuridine moiety of DNA is among the most frequently occurring genomic modifications. Three different routes can result in genomic uracil, two of which do not require specific enzymes: spontaneous cytosine deamination due to the inherent chemical reactivity of living cells, and thymine-replacing incorporation upon ...
Angéla Békési, Eszter Holub, Hajnalka Laura Pálinkás, Beáta G. Vértessy   +3 more
openaire   +3 more sources

Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Frontiers in Immunology, 2021
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase ...
Marina Alexeeva, Marivi Nabong Moen, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Lene Alsøe, Hilde Nilsen, Hilde Nilsen, Svein Bjelland, Svein Bjelland   +13 more
doaj   +1 more source

Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil [PDF]

, 2013
Archaeal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering uracil in template strands, four bases ahead of the primer-template junction. Should the polymerase progress further towards the uracil, for example,
Allan, Aller, Anita C. Jones, Bandwar, Beechem, Beese, Bernard A. Connolly, Bloom, Brautigam, Brian J. Keith, Connolly, Connolly, Connolly, Datta, Emptage, Evans, Firbank, Fogg, Gill, Greagg, Guest, Hariharan, Hogg, Hogg, Jean, Joyce, Joyce, Keith, Killelea, Law, McCullough, Neely, Neely, Pauline Heslop, Record, Reha-Krantz, Reha-Krantz, Reid, Russell, Shamoo, Shuttleworth, Stivers, Stivers, Stocki, Subuddhi, Tomas T. Richardson, Trzenecka, Xiaohua Wu, Youngblood   +48 more
core   +1 more source

Excitation-dependent fluorescence from atomic/molecular layer deposited sodium-uracil thin films

Scientific Reports, 2017
Atomic/molecular layer deposition (ALD/MLD) offers unique possibilities in the fabrication of inorganic-organic thin films with novel functionalities.
V. Pale, Zivile Giedraityte, Xi Chen, O. Lopez-Acevedo, I. Tittonen, M. Karppinen   +5 more
semanticscholar   +1 more source

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections [PDF]

, 2018
Indexación: Scopus.A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class
Alarcón, P., Andrades-Lagos, J., Bollo Dragnic, S., Campanini-Salinas, J., Choquesillo-Lazarte, D., Faúndez, M., Gonzalez Rocha, G., Kogan, M., Mella, J., Recabarren Gajardo, G., Salas-Huenuleo, E., Silva, F., Vidal, R., Vásquez-Velásquez, D.   +13 more
core   +1 more source

Carbonic anhydrase inhibitory properties of some uracil derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI
Emir Alper Türkoğlu, M. Şentürk, C. Supuran, D. Ekinci   +3 more
semanticscholar   +1 more source