Results 161 to 170 of about 22,593 (200)
Some of the next articles are maybe not open access.
Receptors responsive to extracellular uracil nucleotides
Drug Development Research, 1998The cloning of P2Y 4 and P2Y 3 (chicken) / P2Y 6 (rat, human) receptors has been the ultimate proof that receptors for pyrimidine nucleotides exist. However, on the basis of their structure these receptors do not constitute a family of their own but belong to the P2Y family, which thus encompasses selective purinoceptors (P2Y 1 , P2Y 11 ), nucleotide
Communi, Didier +4 more
openaire +2 more sources
Uracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation
Biochemical Pharmacology, 2008Uracil nucleotides (i.e., UTP and UDP) have been known for years as fundamental intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether represent key building blocks for nucleic acid synthesis. In addition, their sugar conjugates (i.e., UDP-glucose and UDP-galactose) enter in several biochemical routes, for example ...
D. Lecca, S. Ceruti
openaire +4 more sources
Effects of galactose on human leukocyte uracil nucleotides
International Journal of Biochemistry, 1975Abstract 1. 1. Uracil nucleotide contents of human leukocytes were determined by enzymatic analysis. The labelling pattern of uracil nucleotides was studied after incubation of the cells in the presence of [ 14 C]uridine followed by separation of the labelled nucleotides by paper chromatography. 2. 2. A depression of UTP, UDP, and UDP-glucose
Dietrich Keppler, Johannes Forster
openaire +2 more sources
Recognition of an Unnatural Difluorophenyl Nucleotide by Uracil DNA Glycosylase
Biochemistry, 2004The DNA repair enzyme uracil DNA glycosylase (UDG) utilizes base flipping to recognize and remove unwanted uracil bases from the genome but does not react with its structural congener, thymine, which differs by a single methyl group. Two factors that determine whether an enzyme flips a base from the duplex are its shape and hydrogen bonding properties.
James T. Stivers +8 more
openaire +3 more sources
Interaction of the Retinal G-Protein Transducin with Uracil Nucleotides
Biochemical and Biophysical Research Communications, 1999Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido ...
Roland Seifert, Jan F. Klinker
openaire +3 more sources
Synthesis of 5-styryl derivatives of uracil nucleosides and nucleotides.
Tetrahedron Letters, 1979Abstract Uracil nucleosides and nucleotides undergo a palladium catalyzed coupling reaction with styrenes to yield the respective 5-substituted derivatives.
Panos Kalaritis +2 more
openaire +2 more sources
Nature Structural & Molecular Biology, 1995
The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 ...
Laurence H. Pearl, Renos Savva
openaire +3 more sources
The Bacillus subtilis bacteriophages PBS-1 and PBS-2 protect their uracil-containing DNA by expressing an inhibitor protein (UGI) which inactivates the host uracil-DNA glycosylase (UDGase) base-excision repair enzyme. Also, PBS1/2 UGI efficiently inactivates UDGases from other biological sources, including the enzyme from herpes simplex virus type-1 ...
Laurence H. Pearl, Renos Savva
openaire +3 more sources
Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake
American Journal of Physiology-Renal Physiology, 1988The biosynthesis of uridine 5'-triphosphate (UTP), uridine 5'-diphosphohexoses, and 5'-diphosphohexosamines (UDP-sugars) was studied in isolated rat glomeruli 48 h after streptozotocin-induced diabetes. Compared with control, diabetic glomeruli demonstrated an increase in the following: exogenous orotate utilization, orotate incorporation into UTP and
Nathan W. Levin +3 more
openaire +3 more sources
Triplet state studies of the nucleoside and nucleotide derivatives of uracil and thymine
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972Abstract Transient absorbing species due to the triplet states of uridine, 5′-uridylic acid, thymidine and 5′-thymidylic acid have been studied by flash photolysis and compared with those of the triplet states of uracil and thymine. These transients are quenched by oxygen and by their ground states with bimolecular rate constants of 6 · 10 8 , 5 · 10
D.W. Whillans, H.E. Johns
openaire +3 more sources
Stimulation of mouse cultured sympathetic neurons by uracil but not adenine nucleotides
Neuroscience, 2001Cultured neurons from the paravertebral sympathetic chain of rats possess excitatory P2X as well as excitatory uracil nucleotide-sensitive P2Y receptors. Preliminary observations had indicated that the analogous neurons of mice lacked P2X receptors. This difference was now investigated.
Nörenberg, Wolfgang +5 more
openaire +4 more sources