Results 1 to 10 of about 3,484 (108)

Deletion of Pleiotrophin protects against high-fat diet-induced liver metabolic disease, independently of the sexual dimorphism in dietary response [PDF]

Molecular Biomedicine
Obesity is a global health problem linked to the development of metabolic syndrome and comorbidities such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Héctor Cañeque-Rufo, Agata Zuccaro, Marta Inmaculada Sanz-Cuadrado, Federica Ruin, Ángela Olivera-Rodríguez, Javier Pizarro-Delgado, María Limones, Jimena Pita-Santibáñez, María Gracia Sánchez-Alonso, Julio Sevillano, Irma García-Martínez, Ángela M. Valverde, Esther Gramage, Gonzalo Herradón, María del Pilar Ramos-Álvarez   +14 more
doaj   +2 more sources

Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance [PDF]

Frontiers in Pharmacology
Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions.
Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Marta Vicente-Rodríguez, Gonzalo Herradón   +9 more
doaj   +2 more sources

Machine learning analysis of kinematic movement features during functional tasks to discriminate chronic neck pain patients from asymptomatic controls [PDF]

Scientific Reports
This study evaluated the discriminative potential of a machine learning model using movement features during functional tasks to distinguish between patients with non-traumatic chronic neck pain and asymptomatic controls. The study included patients with
Filippo Moggioli, Óscar Rodríguez-López, Elena Bocos-Corredor, Constantino Antonio García, Sonia Liébana, Tomás Pérez-Fernández, Cristina Sánchez, Susan Armijo-Olivo, José Angel Santos-Paz, Aitor Martín-Pintado-Zugasti   +9 more
doaj   +2 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources

Identification of key upper-limb muscles during a standardized reach-to-grasp task toward simplified clinical protocols [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionVariability in task execution, target properties, and recording procedures has limited the development of standardized upper-limb surface electromyography (sEMG) reference patterns.
Carmen Cabezaolias, Sergio Garcia, Cristina Sanchez, Rodrigo Rodriguez, Rafael Raya, Eloy Urendes   +5 more
doaj   +2 more sources

Gut Resistome and Hearing Loss in Young Adults: A Preliminary Study on the Interplay Between Microbial Resistance and Auditory Health [PDF]

Antibiotics
Background: Hearing loss (HL) affects more than 1.5 billion people worldwide and represents a major global health concern. Recent evidence suggests that alterations in gut microbial composition and antimicrobial resistance (AMR) may be linked to ...
Julia Almazán-Catalán, Paula Carpizo-Zaragoza, Diana Penalba-Iglesias, María Luisa Sánchez, Daniel González-Reguero, Sara Bueno, Marina Robas-Mora, Gregorio Varela-Moreiras, Teresa Partearroyo, Pedro Jiménez-Gómez   +9 more
doaj   +2 more sources

Early Disclosure of Blood‐Based Biomarkers Optimizes Alzheimer's Disease Management and Treatment Initiation: the PLASMAR study [PDF]

Alzheimers Dement
Abstract Background Blood‐based biomarkers (BBMs) offer a cost‐effective, non‐invasive approach for detecting Alzheimer's disease (AD) pathology, but their impact on improving diagnostic certainty and patient management remains unclear. The PLASMAR study is a prospective, single‐center, blinded, randomized controlled trial assessing the effect of early
Estragués‐Gázquez I, Contador J, Martinez L, Fernández‐Lebrero A, Iaccarino G, Garcia‐Escobar G, Manero‐Borràs R, Navalpotro‐Gómez I, Grau‐Rivera O, Ortiz‐Romero P, Diego‐Osaba M, Blasco‐Forniés H, Jiménez‐Moyano E, Torres‐Torronteras J, Sánchez J, Padrós A, Villoslada P, del Campo M, Puig‐Pijoan A, Suarez‐Calvet M.   +19 more
europepmc   +2 more sources

Effect of a Gluten-Free Diet on the Intestinal Microbiota of Women with Celiac Disease [PDF]

Antibiotics
Background/Objectives: Celiac disease (CD) is an autoimmune disorder characterized by small intestinal enteropathy triggered by gluten ingestion, often associated with gut dysbiosis. The most effective treatment is strict adherence to a gluten-free diet (
M. Mar Morcillo Serrano, Paloma Reche-Sainz, Daniel González-Reguero, Marina Robas-Mora, Rocío de la Iglesia, Natalia Úbeda, Elena Alonso-Aperte, Javier Arranz-Herrero, Pedro A. Jiménez-Gómez   +8 more
doaj   +2 more sources

Active Neurodynamic Technique at Home in Patients with Knee Osteoarthritis: An Open Single Arm Clinical Trial [PDF]

Medicina
Background and Objectives: Knee osteoarthritis (KO) stands as the third leading cause of disability among the elderly, causing pain, reduced quality of life, and decreased functionality.
Beatriz Serrano-García, Carmen Belén Martínez-Cepa, Francisco Forriol, Juan Carlos Zuil-Escobar   +3 more
doaj   +2 more sources

Effect of focal muscle vibration on sEMG activity during repeated elbow movements in healthy adults [PDF]

Journal of NeuroEngineering and Rehabilitation
Background Focal muscle vibration (FMV) is a non-invasive intervention that can modulate neuromuscular excitability, traditionally assessed with electrostimulation-evoked responses like F-waves or H-reflexes, which can be uncomfortable and impractical ...
Carmen Cabezaolias, Rafael Raya, Cristina Sanchez, Rodrigo Rodriguez, Eloy Urendes   +4 more
doaj   +2 more sources