Results 21 to 30 of about 2,310,068 (246)

Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling

Molecules, 2023
When the expression of NOS2 in M1-polarized macrophages is induced, huge amounts of nitric oxide (•NO) are produced from arginine and molecular oxygen as the substrates.
Junichi Fujii, Tsukasa Osaki
doaj   +1 more source

Urea Cycle Disorders in Neonates: Six Case Reports

Journal of Pediatric Research, 2017
Urea cycle disorders are a group of diseases associated with hyperammonemia, which causes severe neurological sequelae, seizures and psychomotor retardation. In this study, six newborn cases diagnosed between 2010-2014 as citrullinemia Type I (four cases)
Kıymet Çelik, Demet Terek, Özgür Olukman, Mehtap Kağnıcı, Şükran Keskin Gözmen, Erkin Serdaroğlu, Şebnem Çalkavur, Sertaç Arslanoğlu   +7 more
doaj   +1 more source

The Molecular Aspect of Nephrolithiasis Development

Cells, 2021
Urolithiasis is the third most common urological disease after urinary tract infections and prostate diseases, and it is characterised by an occurrence rate of about 15%, which continues to rise. The increase in the incidence of kidney stones observed in
Paulina Wigner, Radosław Grębowski, Michal Bijak, Janusz Szemraj, Joanna Saluk-Bijak   +4 more
doaj   +1 more source

Urea cycle disorder presenting as bilateral mesial temporal sclerosis – an unusual cause of seizures: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Urea cycle disorders are secondary to defects in the system converting ammonia into urea, causing accumulation of ammonia and other byproducts which are neurotoxic.
Furene Sijia Wang, Denise Li Meng Goh, Hian Tat Ong   +2 more
doaj   +1 more source

The challenge of understanding and predicting phenotypic diversity in urea cycle disorders

, 2023
The Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) are the worldwide largest databases for individuals with urea cycle disorders (UCDs) comprising longitudinal data from more ...
Posset, Roland, Gleich, Florian, Kölker, Stefan, Urea Cycle Disorders Consortium (UCDC), Sokal, Etienne, European registry and network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group, Hoffmann, Georg F., Zielonka, Matthias, Garbade, Sven F.   +8 more
core   +1 more source

Dietary N-carbamylglutamate supplementation improves ammonia tolerance of juvenile yellow catfish Pelteobagrus fulvidraco

Frontiers in Physiology, 2023
Introduction: Ammonia has been of concern for its high toxicity to animals. N-carbamylglutamate (NCG) can reduce blood ammonia levels in mammals, but studies on ammonia tolerance in fish are insufficient.Methods: Juvenile yellow catfish were fed two ...
Dexiang Feng, Zhiguo Yang, Ming Li
doaj   +1 more source

Enhanced Productivity of a Lutein-Enriched Novel Acidophile Microalga Grown on Urea [PDF]

, 2010
Coccomyxa acidophila is an extremophile eukaryotic microalga isolated from the Tinto River mining area in Huelva, Spain. Coccomyxa acidophila accumulates relevant amounts of b-carotene and lutein, well-known carotenoids with many biotechnological ...
Vilchez, C., Casal Bejarano, Carlos, Carlos Vilchez, Maria Cuaresma, Cuaresma, María, Casal, C., Casal, Carlos, Jose Maria Vega, Vilchez Lobato, Carlos, Cuaresma Franco, María, Vega, J.M., Cuaresma, M., Carlos Casal, Vega Piqueres, José María   +13 more
core   +1 more source

Recurrent hyperammonaemia in a patient with carbonic anhydrase VA deficiency

JIMD Reports, 2022
Carbonic anhydrase VA deficiency is a recently described inherited cause of paediatric hyperammonaemia. Most published cases describe patients with only one episode of hyperammonaemia whilst others report patients who had up to three metabolic crises ...
Christopher Stockdale, Ann Bowron, Marie Appleton, Ruth Richardson, Mark Anderson   +4 more
doaj   +1 more source

Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency

Molecular Therapy: Nucleic Acids, 2022
Arginase deficiency is associated with prominent neuromotor features, including spastic diplegia, clonus, and hyperreflexia; intellectual disability and progressive neurological decline are other signs.
Suhail Khoja, Xiao-Bo Liu, Brian Truong, Matthew Nitzahn, Jenna Lambert, Adam Eliav, Eram Nasser, Emma Randolph, Kristine E. Burke, Rebecca White, Xuling Zhu, Paolo G.V. Martini, Itzhak Nissim, Stephen D. Cederbaum, Gerald S. Lipshutz   +14 more
doaj   +1 more source

Relationship between longitudinal changes in neuropsychological outcome and disease biomarkers in urea cycle disorders

, 2023
BACKGROUND: Urea cycle disorders (UCDs) cause impaired conversion of waste nitrogen to urea leading to rise in glutamine and ammonia. Elevated ammonia and glutamine have been implicated in brain injury.
McCarter, Robert, Sanz, Jacqueline H, Baumgartner, Matthias R; https://orcid.org/, et al, Urea Cycle Disorders Consortium, Lichter-Konecki, Uta   +5 more
core   +1 more source