Results 101 to 110 of about 151,121 (186)

The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin [PDF]

, 2017
Lanthionine is a nonproteinogenic amino acid, composed of two alanine residues that are crosslinked on their β-carbon atoms by a thioether linkage.
Diego Ingrosso, Ingrosso, D., Trepiccione, F, Alessandra Perna, Miriam Zacchia, Zacchia, M, Perna, A, Alessandra F. Perna, Francesco Trepiccione   +8 more
core   +1 more source

Toxicity of Cytarabine Intravenous Constant Rate Infusion in Cats With Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Cytarabine intravenous constant rate infusion (IV CRI) toxicity in cats with lymphoma has not been well documented. We aimed to assess toxicities following cytarabine IV CRI as a single‐agent or within a multiagent protocol in cats with lymphoma. Medical records of cats with lymphoma treated with cytarabine IV CRI, with documented dose, route,
Rachel Hanford, Katherine A. Skorupski, Robert B. Rebhun, Rachel V. Brady, Sami Al‐Nadaf, Amandine T. Lejeune   +5 more
wiley   +1 more source

Beyond Hemodynamics

JACC: Basic to Translational Science
Summary: Uremic cardiomyopathy has traditionally been attributed to pressure overload, volume overload, hypertension, and neurohormonal activation in chronic kidney disease.
Elchanan Parnasa, MD, Yair Rokach, PhD, Suzan Abedat, PhD, Offer Amir, MD, Iddo Z. Ben-Dov, MD, PhD, Rabea Asleh, MD, PhD, MHA   +5 more
doaj   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Membrane-to-Patient Optimization: Individualized Dialyzer Selection for Extracorporeal Dialysis

Toxins
Extracorporeal dialysis for uremic toxin removal and fluid regulation relies on specialized dialyzers whose membranes differ markedly in polymer chemistry, pore architecture, adsorption capacity, surface bioactivity, and convective performance.
Mariana Murea, Alaa S. Awad, Vandana D. Niyyar, Tibor Fülöp, Akihiro C. Yamashita, Tadashi Tomo, Masanori Abe   +6 more
doaj   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Association between chronic kidney disease and the risk of myelodysplastic syndromes: A large claims database study in Japan

British Journal of Haematology, EarlyView.
Yuta Baba, Takehiko Sambe, Tetsuya Fukuda, Tatsunori Oguchi, Kenji Momo   +4 more
wiley   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Dicarboxymethyl Cellulose‐Based Mixed‐Matrix Membrane Adsorbers: Preparation, Characterization, and Protein Retention Performance

Journal of Applied Polymer Science, Volume 143, Issue 47, December 15, 2026.
Dicarboxymethyl cellulose is incorporated, for the first time, into a polyethersulfone membrane. The functional membranes are prepared using dimethyl isosorbide through combined non‐solvent and vapor‐induced phase separation. The resulting membranes exhibit porous structures and protein‐retention potential, highlighting the potential of this cellulose ...
Diana Gago, Giuseppe Di Luca, Francesca Russo, Ricardo Chagas, Luísa Maria Ferreira, Francesco Galiano, Isabel Coelhoso, Alberto Figoli   +7 more
wiley   +1 more source

Comparable Efficacy of Medium Cut-Off Dialysis Plus HA130 Hemoadsorption and Postfilter Hemodiafiltration in Removing Protein-Bound Uremic Toxins

Kidney Medicine
Rationale & Objective: Protein-bound uremic toxins, including indoxyl sulfate and p-cresyl sulfate, are poorly removed by conventional dialysis and contribute to cardiovascular, inflammatory, and neurological complications in end-stage kidney disease.
Gonzalo Ramírez-Guerrero, Cristian Pedreros-Rosales, María José Cáceres, Katherine Saravia, Alejandra Urizar, Armando Rojas, Thiago Reis, Hans Müller-Ortiz, Claudio Ronco   +8 more
doaj   +1 more source