Results 81 to 90 of about 25,775 (238)

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Timeliness of Surveillance during Outbreak of Shiga Toxin–producing Escherichia coli Infection, Germany, 2011

Emerging Infectious Diseases, 2011
In the context of a large outbreak of Shiga toxin–producing Escherichia coli O104:H4 in Germany, we quantified the timeliness of the German surveillance system for hemolytic uremic syndrome and Shiga toxin–producing E.
Mathias Altmann, Anke Spode, Doris Altmann, Maria Wadl, Justus Benzler, Tim Eckmanns, Gérard Krause, Matthias an der Heiden   +7 more
doaj   +1 more source

Geogenomic segregation and temporal trends of human pathogenic Escherichia coli o157:H7, Washington, USA, 2005-2014 [PDF]

, 2018
The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E.
Besser, Thomas E, Mayer, Jonathan, Oltean, Hanna N, Phipps, Amanda I, Rabinowitz, Peter, Shringi, Smriti, Tarr, Gillian A. M., Tarr, Phillip I, Wakefield, Jon   +8 more
core   +3 more sources

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Invasive Streptococcus pneumoniae Infection Causing Hemolytic Uremic Syndrome in Children: Two Recent Cases

Canadian Journal of Infectious Diseases, 2003
INTRODUCTION: Streptococcus pneumoniae is an uncommon cause of hemolytic uremic syndrome (HUS) with a unique pathophysiology that differs from Shiga toxin-related HUS.
Otto G Vanderkooi, James D Kellner, Andrew W Wade, Tajdin Jadavji, Julian P Midgley, Thomas Louie, Gregory J Tyrrell   +6 more
doaj   +1 more source

Insight into Shiga toxin genes encoded by Escherichia coli O157 from whole genome sequencing [PDF]

, 2015
The ability of Shiga toxin-producing Escherichia coli (STEC) to cause severe illness in humans is determined by multiple host factors and bacterial characteristics, including Shiga toxin (Stx) subtype.
Asadulghani, Asakura, Bolger, Chaisson, Cock, De Baets, Eppinger, Ethelberg, Hayashi, Hegde, Jenkins, Joensen, Lee, Li, Loman, Luna-Gierke, Mellor, Pennington, Persson, Scheutz, Tamura, Zerbino   +21 more
core   +2 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

Associations between body mass index categories and geriatric assessment tests among older adults with chronic kidney disease: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background The optimal body mass index (BMI) among older adults with chronic kidney disease (CKD) in geriatric assessment tests has not been studied. This study investigates the relationship between BMI and Comprehensive Geriatric Assessment (CGA) parameters among older adults with CKD.
Yelda Deligöz Bildaci, Cihan Heybeli, Lee Smith, Masoud Rahmati, Dong Keon Yon, Pinar Soysal   +5 more
wiley   +1 more source

Primary Thrombotic Microangiopathy in Pediatric Patients

Global Pediatric Health
Background . Primary thrombotic microangiopathy includes hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli , atypical hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Methodology .
Andrés David Aranzazu Ceballos MD, Lina María Martínez Sánchez MSc, Ana Paulina Pamplona Sierra MD, Daniela Vergara Yánez MD, Liliana Franco Hincapié PhD, Richard Baquero Rodriguez MD   +5 more
doaj   +1 more source