Results 61 to 70 of about 151,121 (186)
Sex-Dependent Determinants of Uremic Toxicity in Chronic Kidney Disease
ToxinsChronic kidney disease (CKD) is characterized by the progressive accumulation of uremic toxins (UTs), which contribute to systemic complications, increased cardiovascular risk, and disease progression.
Oriana Nobus +3 more
doaj +1 more source
Special Issue: Shiga Toxin-Producing Escherichia coli
Microorganisms, 2020 Globally, Shiga toxin-producing Escherichia coli (STEC) is an important cause of diarrheal disease, most notably hemorrhagic colitis, and post-diarrheal sequela, such as hemolytic-uremic syndrome (HUS) [...]
Rodney A. Moxley
doaj +1 more source
iNew Medicine, EarlyView.Structural cells (endothelial, epithelial, neural, and muscle) actively participate in innate immunity as primary responders, challenging the traditional leukocyte‐centric paradigm and opening new therapeutic avenues for precision medicine. ABSTRACT Innate immunity has long been viewed as the domain of circulating mobile immune cells orchestrating ...
Sofya Urvanova, Suowen Xu
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang +22 more
wiley +1 more source
Uric Acid – A Uremic Toxin? [PDF]
Blood Purification, 2005 Uric acid might often be regarded as a simple marker of renal disease. Although it is well known that hyperuricemia causes gout which is associated with renal insufficiency and cardiovascular disease, one might think that it could attribute to the intrarenal urate crystal, but not to uric acid per se.
Takahiko, Nakagawa +5 more
openaire +2 more sources
JEADV Clinical Practice, EarlyView.Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll +6 more
wiley +1 more source
Comprehensive Bibliometric Analysis of Uremic Toxin Research
Uremic toxins accumulate as kidney disease progresses, contributing to diverse systemic disorders. Despite numerous studies, no comprehensive mapping has been performed.
Takuya Wakamatsu +9 more
core +1 more source
Med Research, EarlyView.This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng +14 more
wiley +1 more source
Microbial Modulation of a Uremic Toxin [PDF]
Cell Host & Microbe, 2016 In this issue of Cell Host & Microbe, Devlin et al. (2016) identify a family of tryptophanases encoded by members of the human gut microbiome and demonstrate that levels of the uremic toxin indoxyl sulfate can be modulated in vivo by altering the abundance of bacteria harboring tryptophanase activity.
Sarah M, Skye, Stanley L, Hazen
openaire +2 more sources
Pathogenesis of Shiga toxin-associated hemolytic uremic syndrome
, 2001 The aim of this review is to examine recent advances in experimental and clinical research relevant to the pathogenesis of diarrhea-associated hemolytic uremic syndrome with special reference to histopathologic findings, virulence factors of Shiga toxin ...
Proulx, Francois +3 more
core +2 more sources