Results 91 to 100 of about 134,815 (339)

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]

, 2009
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Güntert, Peter, Inoue, Makoto, Kigawa, Takanori, Kobayashi, Naohiro, Kuwasako, Kanako, Muto, Yutaka, Shirouzu, Mikako, Someya, Tatsuhiko, Sugano, Sumio, Takahashi, Mari, Tanaka, Akiko, Terada, Takaho, Tsuda, Kengo, Yokoyama, Shigeyuki   +13 more
core   +2 more sources

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Synthesis and cytotoxic activity of tri-acyl ester derivatives of uridine in breast cancer cells

Ars Pharmaceutica, 2016
Aims: Synthesize tri-acyl ester derivatives of uridine, and evaluate its cytotoxicity against breast cancer cells line. Methods: The tri-esterified uridine derivatives were obtained through Steglich esterification reaction by fatty and aromatic acids ...
Jhon Fernando Berrío Escobar, Víctor Hugo Arango Carmona, Elkin Galeano Jaramillo, Diana Margarita Márquez Fernández, María Elena Márquez Fernández, Mauricio Camargo Guerrero, Alejandro Martínez Martínez   +6 more
doaj   +1 more source

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. [PDF]

, 2014
Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S.
Cunningham, Mark L, Fenical, William, Haste, Nina M, Hensler, Mary E, Jang, Kyoung Hwa, Kwan, Bryan P, Lin, Leo, Nizet, Victor, Shaw, Karen Joy, Soubih, Evaristus, Thienphrapa, Wdee, Tran, Dan N, Vuong, Lisa   +12 more
core   +1 more source

The Effect of E. coli Uridine-Cytidine Kinase Gene Deletion on Cytidine Synthesis and Transcriptome Analysis [PDF]

, 2022
Fengmin Liu, Tong Ye, Xiangjun Zhang, Cong Ma, Huiyan Liu, Haitian Fang   +5 more
openalex   +1 more source

Unexpected Accumulation of ncm\u3csup\u3e5\u3c/sup\u3eU and ncm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU in a \u3cem\u3etrm9\u3c/em\u3e Mutant Suggests an Additional Step in the Synthesis of mcm\u3csup\u3e5\u3c/sup\u3eU and mcm\u3csup\u3e5\u3c/sup\u3es\u3csup\u3e2\u3c/sup\u3eU [PDF]

, 2011
Background Transfer RNAs are synthesized as a primary transcript that is processed to produce a mature tRNA. As part of the maturation process, a subset of the nucleosides are modified.
Anderson, James T., Byström, Anders S., Chen, Changchun, Huang, Bo   +3 more
core   +1 more source

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand [PDF]

, 2014
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands.
Barrett, Matthew O, Brown, Kyle A, Harden, T Kendall, Karalic, Izet, Risseeuw, Martijn, Song, Lijun, Van Calenbergh, Serge   +6 more
core   +4 more sources

Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease

Frontiers in Immunology
IntroductionInflammatory bowel disease (IBD), a chronic immune-mediated gastrointestinal disorder mainly covering Crohn's Disease and Ulcerative Colitis, has an unclear etiology.
Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai   +10 more
doaj   +1 more source

Calcium-binding capacity of organic and inorganic ortho- and polyphosphates [PDF]

The aim of this research was to determine the calcium-binding capacity of inorganic and organic ortho- and polyphosphates. This calcium-binding capacity can be used to influence the stability of, for example, casein micelles in dairy systems.
Hooijdonk, A.C.M., van, Kort, E.J.P., de, Linden, E., van der, Minor, M., Snoeren, T.H.M.   +4 more
core   +2 more sources

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source