Results 41 to 50 of about 99,858 (332)
Разработка и регистрация лекарственных средств, 2023 Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa +8 more
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Beilstein Journal of Organic Chemistry, 2017 The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivities (65 ...
Raja Ben Othman +4 more
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Molecules, 2013 New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1–4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were ...
Ilona Wandzik +5 more
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Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics
Molbank, 2020 Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents.
Kristin Leyerer +2 more
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Low Turnover of Soil Bacterial rRNA at Low Temperatures
Frontiers in Microbiology, 2020 Ribosomal RNA (rRNA) is used widely to investigate potentially active microorganisms in environmental samples, including soil microorganisms and other microbial communities that are subjected to pronounced seasonal variation in temperature. This raises a
Morten Dencker Schostag +8 more
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From Formamide to RNA, the Path Is Tenuous but Continuous
Life, 2015 Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino +4 more
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Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Phosphorylation is essential for life. Phosphorylated molecules play diverse functions in cells, including metabolic (e.g., sugar phosphates), structural (e.g., phospholipids), and instructional (e.g., RNA and DNA).
Inho Nam, Jae Kyoo Lee, H. Nam, R. Zare
semanticscholar +1 more source
mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells
Pharmaceutics, 2018 The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG cells, although these ...
Abdullah Mayati +6 more
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BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance It is believed that the Bcl-2 family protein Bok has a redundant role similar to Bax and Bak in regulating apoptosis. We report that this protein interacts with the key enzyme involved in uridine biosynthesis, uridine monophosphate ...
Rahul Srivastava +24 more
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Case Report: Rapid Treatment of Uridine-Responsive Epileptic Encephalopathy Caused by CAD Deficiency
Frontiers in Pharmacology, 2020 We present two unrelated Chinese patients with CAD deficiency manifesting with a triad of infantile-onset psychomotor developmental delay with regression, drug-refractory epilepsy, and anaemia with anisopoikilocytosis.
Ling Zhou +10 more
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