Results 41 to 50 of about 98,911 (236)
Beilstein Journal of Organic Chemistry, 2017 The 5’-alkynylation of uridine-derived aldehydes is described. The addition of alkynyl Grignard reagents on the carbonyl group is significantly influenced by the 2’,3’-di-O-protecting groups (R1): O-alkyl groups led to modest diastereoselectivities (65 ...
Raja Ben Othman +4 more
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Case Report: Rapid Treatment of Uridine-Responsive Epileptic Encephalopathy Caused by CAD Deficiency
Frontiers in Pharmacology, 2020 We present two unrelated Chinese patients with CAD deficiency manifesting with a triad of infantile-onset psychomotor developmental delay with regression, drug-refractory epilepsy, and anaemia with anisopoikilocytosis.
Ling Zhou +10 more
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Low Turnover of Soil Bacterial rRNA at Low Temperatures
Frontiers in Microbiology, 2020 Ribosomal RNA (rRNA) is used widely to investigate potentially active microorganisms in environmental samples, including soil microorganisms and other microbial communities that are subjected to pronounced seasonal variation in temperature. This raises a
Morten Dencker Schostag +8 more
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Antioxidants, 2022 The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear.
Rong Xu +7 more
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Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine
Acta Crystallographica Section E: Crystallographic Communications, 2017 The molecule of the title compound, C21H18N2O6, has a bent rather than a linear conformation supported by three intramolecular C—H...O hydrogen bonds. The packing in the crystal lattice is largely determined by interactions between hydrogen atoms with ...
Vijay Gayakhe +3 more
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Abiotic production of sugar phosphates and uridine ribonucleoside in aqueous microdroplets
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Phosphorylation is essential for life. Phosphorylated molecules play diverse functions in cells, including metabolic (e.g., sugar phosphates), structural (e.g., phospholipids), and instructional (e.g., RNA and DNA).
Inho Nam, Jae Kyoo Lee, H. Nam, R. Zare
semanticscholar +1 more source
BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance It is believed that the Bcl-2 family protein Bok has a redundant role similar to Bax and Bak in regulating apoptosis. We report that this protein interacts with the key enzyme involved in uridine biosynthesis, uridine monophosphate ...
Rahul Srivastava +24 more
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Honey as Source of Nitrogen Compounds: Aromatic Amino Acids, Free Nucleosides and Their Derivatives
Molecules, 2020 The content of selected major nitrogen compounds including nucleosides and their derivatives was evaluated in 75 samples of seven varieties of honey (heather, buckwheat, black locust, goldenrod, canola, fir, linden) by targeted ultra-high performance ...
Piotr M. Kuś
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Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization
ACTA Pharmaceutica Sciencia, 2019 Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The farreaching effects of pharmacological uridine have long been neglected.
S. R. Devi +6 more
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Wobble uridine modifications–a reason to live, a reason to die?!
RNA Biology, 2017 Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-
R. Schaffrath, Sebastian A. Leidel
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