Results 51 to 60 of about 98,911 (236)

Synthesis of uridine derivatives

Communications, Faculty Of Science, University of Ankara Series B Chemistry and Chemical Engineering, 1992
2', 3'-0 isopropylidene-5-ammomethyl uridine was condensed with some aldehydes. in the şame time, reduçtion 44in situ” of the reaction products was achieved Ncvçrtheless, the resulting compounds showed to be unstable during chromatographic processes.
openaire   +3 more sources

Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study

Scientific Reports, 2023
Uridine, a pyrimidine nucleoside, is crucial in the synthesis of metabolites. According to observational studies, a higher plasma uridine level is associated with a lower risk of atrial fibrillation (AF).
Xintian Xu, Xiaoyu Zhang, Shiyao Cheng, Qinglang Li, Cai Chen, Mao Ouyang   +5 more
doaj   +1 more source

Emergency use of uridine triacetate for the prevention and treatment of life‐threatening 5‐fluorouracil and capecitabine toxicity

Cancer, 2016
Increased susceptibility to 5‐fluorouracil (5‐FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5‐FU.
W. Ma, M. Saif, B. El-Rayes, M. Fakih, T. Cartwright, J. Posey, Thomas King, R. V. von Borstel, M. Bamat   +8 more
semanticscholar   +1 more source

Lipidomic and transcriptomic profiles provide new insights into the triacylglycerol and glucose handling capacities of the Arctic fox

Frontiers in Veterinary Science
The Arctic fox (Vulpes lagopus) is a species indigenous to the Arctic and has developed unique lipid metabolism, but the mechanisms remain unclear.
Yuhang Zhu, Yuan Yuan, Huazhe Si, Huazhe Si, Songze Li, Fei Zhao, Ruina Mu, Zihan Lin, Xiaoxu Wang, Qiang Qiu, Chao Xu, Lele Ji, Zhipeng Li, Zhipeng Li   +13 more
doaj   +1 more source

Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement. [PDF]

PLoS ONE, 2011
Uridine is a therapy for hereditary orotic aciduria and is being investigated in other disorders caused by mitochondrial dysfunction, including toxicities resulting from treatment with nucleoside reverse transcriptase inhibitors in HIV. Historically, the
Melissa E Weinberg, Mark C Roman, Peyton Jacob, Michael Wen, Polly Cheung, Ulrich A Walker, Kathleen Mulligan, Morris Schambelan   +7 more
doaj   +1 more source

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

Nutritional neuroscience, 2017
Recent investigations have focused on the potential role of gastrointestinal (GI) abnormalities in the pathogenesis of Parkinson's disease (PD). The ‘dual-hit’ hypothesis of PD speculates that a putative pathogen enters the brain via two routes: the ...
P. Perez‐Pardo, H. Dodiya, L. Broersen, H. Douna, N. van Wijk, S. Lopes da Silva, J. Garssen, A. Keshavarzian, A. Kraneveld   +8 more
semanticscholar   +1 more source

Anti-Inflammatory Responses Produced with Nippostrongylus brasiliensis-Derived Uridine via the Mitochondrial ATP-Sensitive Potassium Channel and Its Anti-Atherosclerosis Effect in an Apolipoprotein E Gene Knockout Mouse Model

Biomolecules
Atherosclerosis (AS) has become the leading cause of cardiovascular disease worldwide. Our previous study had observed that Nippostrongylus brasiliensis (Nb) infection or its derived products could inhibit AS development by inducing an anti-inflammatory ...
Yingshu Zhang, Xin Ding, Caiyi Yuan, Yougui Yang, Qiang Zhang, Jiakai Yao, Ying Zhang, Junhong Wang, Yang Dai   +8 more
doaj   +1 more source

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

Frontiers in Cellular and Infection Microbiology, 2023
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited.
Hamza A. A. Elati, Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Lilach Sheiner, Harry P. de Koning   +6 more
doaj   +1 more source

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer [PDF]

Oncogene, 2006
The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to their substrate specificity, tissue expression and gene structure.
Nagar, S., Remmel, R. P.
openaire   +3 more sources

Synthesis and cytotoxic activity of tri-acyl ester derivatives of uridine in breast cancer cells

Ars Pharmaceutica, 2016
Aims: Synthesize tri-acyl ester derivatives of uridine, and evaluate its cytotoxicity against breast cancer cells line. Methods: The tri-esterified uridine derivatives were obtained through Steglich esterification reaction by fatty and aromatic acids ...
Jhon Fernando Berrío Escobar, Víctor Hugo Arango Carmona, Elkin Galeano Jaramillo, Diana Margarita Márquez Fernández, María Elena Márquez Fernández, Mauricio Camargo Guerrero, Alejandro Martínez Martínez   +6 more
doaj   +1 more source