Results 51 to 60 of about 99,858 (332)

Uridine Prevents Negative Effects of OXPHOS Xenobiotics on Dopaminergic Neuronal Differentiation

Cells, 2019
Neuronal differentiation appears to be dependent on oxidative phosphorylation capacity. Several drugs inhibit oxidative phosphorylation and might be detrimental for neuronal differentiation.
Eldris Iglesias, M. Pilar Bayona-Bafaluy, Alba Pesini, Nuria Garrido-Pérez, Patricia Meade, Paula Gaudó, Irene Jiménez-Salvador, Julio Montoya, Eduardo Ruiz-Pesini   +8 more
doaj   +1 more source

Microbial efficacy and two step synthesis of uridine derivatives with spectral characterization

ACTA Pharmaceutica Sciencia, 2019
Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The farreaching effects of pharmacological uridine have long been neglected.
S. R. Devi, Sanjida Jesmin, M. Rahman, M. A. Manchur, Y. Fujii, Y. Ozeki, S. Kawsar   +6 more
semanticscholar   +1 more source

Synthesis and cytotoxic activity of tri-acyl ester derivatives of uridine in breast cancer cells

Ars Pharmaceutica, 2016
Aims: Synthesize tri-acyl ester derivatives of uridine, and evaluate its cytotoxicity against breast cancer cells line. Methods: The tri-esterified uridine derivatives were obtained through Steglich esterification reaction by fatty and aromatic acids ...
Jhon Fernando Berrío Escobar, Víctor Hugo Arango Carmona, Elkin Galeano Jaramillo, Diana Margarita Márquez Fernández, María Elena Márquez Fernández, Mauricio Camargo Guerrero, Alejandro Martínez Martínez   +6 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

FEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa, Yasushi Shigeri, Shingo Fujisaki   +2 more
wiley   +1 more source

Anti-Inflammatory Responses Produced with Nippostrongylus brasiliensis-Derived Uridine via the Mitochondrial ATP-Sensitive Potassium Channel and Its Anti-Atherosclerosis Effect in an Apolipoprotein E Gene Knockout Mouse Model

Biomolecules
Atherosclerosis (AS) has become the leading cause of cardiovascular disease worldwide. Our previous study had observed that Nippostrongylus brasiliensis (Nb) infection or its derived products could inhibit AS development by inducing an anti-inflammatory ...
Yingshu Zhang, Xin Ding, Caiyi Yuan, Yougui Yang, Qiang Zhang, Jiakai Yao, Ying Zhang, Junhong Wang, Yang Dai   +8 more
doaj   +1 more source

Wobble uridine modifications–a reason to live, a reason to die?!

RNA Biology, 2017
Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-
R. Schaffrath, Sebastian A. Leidel
semanticscholar   +1 more source

Synthesis of uridine derivatives

Communications, Faculty Of Science, University of Ankara Series B Chemistry and Chemical Engineering, 1992
2', 3'-0 isopropylidene-5-ammomethyl uridine was condensed with some aldehydes. in the şame time, reduçtion 44in situ” of the reaction products was achieved Ncvçrtheless, the resulting compounds showed to be unstable during chromatographic processes.
openaire   +3 more sources

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Lipidomic and transcriptomic profiles provide new insights into the triacylglycerol and glucose handling capacities of the Arctic fox

Frontiers in Veterinary Science
The Arctic fox (Vulpes lagopus) is a species indigenous to the Arctic and has developed unique lipid metabolism, but the mechanisms remain unclear.
Yuhang Zhu, Yuan Yuan, Huazhe Si, Huazhe Si, Songze Li, Fei Zhao, Ruina Mu, Zihan Lin, Xiaoxu Wang, Qiang Qiu, Chao Xu, Lele Ji, Zhipeng Li, Zhipeng Li   +13 more
doaj   +1 more source