Results 61 to 70 of about 99,858 (332)

Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study

Scientific Reports, 2023
Uridine, a pyrimidine nucleoside, is crucial in the synthesis of metabolites. According to observational studies, a higher plasma uridine level is associated with a lower risk of atrial fibrillation (AF).
Xintian Xu, Xiaoyu Zhang, Shiyao Cheng, Qinglang Li, Cai Chen, Mao Ouyang   +5 more
doaj   +1 more source

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer [PDF]

Oncogene, 2006
The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to their substrate specificity, tissue expression and gene structure.
Nagar, S., Remmel, R. P.
openaire   +3 more sources

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Emergency use of uridine triacetate for the prevention and treatment of life‐threatening 5‐fluorouracil and capecitabine toxicity

Cancer, 2016
Increased susceptibility to 5‐fluorouracil (5‐FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5‐FU.
W. Ma, M. Saif, B. El-Rayes, M. Fakih, T. Cartwright, J. Posey, Thomas King, R. V. von Borstel, M. Bamat   +8 more
semanticscholar   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement. [PDF]

PLoS ONE, 2011
Uridine is a therapy for hereditary orotic aciduria and is being investigated in other disorders caused by mitochondrial dysfunction, including toxicities resulting from treatment with nucleoside reverse transcriptase inhibitors in HIV. Historically, the
Melissa E Weinberg, Mark C Roman, Peyton Jacob, Michael Wen, Polly Cheung, Ulrich A Walker, Kathleen Mulligan, Morris Schambelan   +7 more
doaj   +1 more source

Gut–brain and brain–gut axis in Parkinson's disease models: Effects of a uridine and fish oil diet

Nutritional neuroscience, 2017
Recent investigations have focused on the potential role of gastrointestinal (GI) abnormalities in the pathogenesis of Parkinson's disease (PD). The ‘dual-hit’ hypothesis of PD speculates that a putative pathogen enters the brain via two routes: the ...
P. Perez‐Pardo, H. Dodiya, L. Broersen, H. Douna, N. van Wijk, S. Lopes da Silva, J. Garssen, A. Keshavarzian, A. Kraneveld   +8 more
semanticscholar   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine

Acta Crystallographica Section E: Crystallographic Communications, 2017
The molecule of the title compound, C21H18N2O6, has a bent rather than a linear conformation supported by three intramolecular C—H...O hydrogen bonds. The packing in the crystal lattice is largely determined by interactions between hydrogen atoms with ...
Vijay Gayakhe, Anant Ramakant Kapdi, Yulia Borozdina, Carola Schulzke   +3 more
doaj   +1 more source

Pyrimidine salvage in Toxoplasma gondii as a target for new treatment

Frontiers in Cellular and Infection Microbiology, 2023
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited.
Hamza A. A. Elati, Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Lilach Sheiner, Harry P. de Koning   +6 more
doaj   +1 more source