Results 61 to 70 of about 98,911 (236)
Uridine-Ribohydrolase Is a Key Regulator in the Uridine Degradation Pathway of Arabidopsis [PDF]
The Plant Cell, 2009 Abstract Nucleoside degradation and salvage are important metabolic pathways but hardly understood in plants. Recent work on human pathogenic protozoans like Leishmania and Trypanosoma substantiates an essential function of nucleosidase activity.
Benjamin Jung +7 more
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From Formamide to RNA, the Path Is Tenuous but Continuous
Life, 2015 Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially
Samanta Pino +4 more
doaj +1 more source
PLoS ONE, 2017 In the present study, a novel breeding strategy of atmospheric and room temperature plasma (ARTP) mutagenesis was used to improve the uridine production of engineered Bacillus subtilis TD12np. A high-throughput screening method was established using both
Xiaoguang Fan +7 more
semanticscholar +1 more source
Journal of Pain Research, 2020 Marco Antonio Naslausky Mibielli,1 Carlos Pereira Nunes,1,2 Henrique Goldberg,3 Luiz Buchman,2 Lisa Oliveira,4 Spyros GE Mezitis,5 Fernanda Wajnzstajn,6 Renato Kaufman,3 Rafael Nigri,7 Natasha Cytrynbaum,3 Karin Soares Cunha,8 Alessandra Santos,4 ...
Mibielli MAN +17 more
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mRNA Expression and Activity of Nucleoside Transporters in Human Hepatoma HepaRG Cells
Pharmaceutics, 2018 The HepaRG cell line is a highly differentiated human hepatoma cell line, displaying the expression of various drug transporters. However, functional expression of nucleoside transporters remains poorly characterized in HepaRG cells, although these ...
Abdullah Mayati +6 more
doaj +1 more source
OncoTarget, 2016 Celastrol, extracted from “Thunder of God Vine”, is a promising anti-cancer natural product. However, its effect on acute promyelocytic leukemia (APL) and underlying molecular mechanism are poorly understood.
Xiaoling Zhang +9 more
semanticscholar +1 more source
Chemical Oxidation of Uridine Diphosphate-Glucose to Uridine Diphosphate-Glucuronic Acid [PDF]
Nature, 1961 THE importance of uronic acids in carbohydrate metabolism has only recently begun to be elucidated. The metabolism of inositol and ascorbate is known to involve uronic acid intermediates1,2, and nucleotide-bound glucuronic acid has been implicated in hyaluronic acid synthesis3.
Eugene A. Davidson, Bernard Jacobson
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The role of wobble uridine modifications in +1 translational frameshifting in eukaryotes
Nucleic Acids Research, 2015 In Saccharomyces cerevisiae, 11 out of 42 tRNA species contain 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U), 5-methoxycarbonylmethyluridine (mcm5U), 5-carbamoylmethyluridine (ncm5U) or 5-carbamoylmethyl-2′-O-methyluridine (ncm5Um) nucleosides in the ...
Hasan Tükenmez +3 more
semanticscholar +1 more source
Compartmentalization of Uridine and Uridine 5′-Monophosphate in Rat Liver Slices
Journal of Biological Chemistry, 1973 Abstract The metabolism of exogenous uridine, uridine 5'-monophosphate, and uracil by rat liver slices was studied using in vitro superfusion systems. Mixtures of 3H- and 14C-labeled uridine, uridine 5'-monophosphate, uracil, and orotic acid were superfused at a constant rate until an isotopic steady state was achieved.
John K. Tseng, Erlio Gurpide
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The Scientific World Journal, 2012 5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or its
J. Hartinger +5 more
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