Results 71 to 80 of about 96,444 (318)

Integrierte chemo‐enzymatische Synthese des mRNA‐Impfstoff‐Bausteins N1‐Methylpseudouridintriphosphat

open access: yesAngewandte Chemie, EarlyView.
Pseudouridin‐5'‐triphosphat (ΨTP) und sein N1‐methyliertes Derivat (m1ΨTP) sind entscheidende Komponenten in der mRNA‐Impfstofftechnologie. Hier wird ein atomökonomischer, ertragreicher biokatalytischer Weg zur Synthese von ΨTP vorgestellt. Zudem wurde ein neuer chemo‐enzymatischer Weg für die m1ΨTP‐Synthese entwickelt.
Martin Pfeiffer   +4 more
wiley   +1 more source

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

open access: yesPediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao   +5 more
doaj   +1 more source

Crigler Najjar Syndrome Type 2 (CNS Type 2): An Unwonted Cause of Jaundice in Adults [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2017
Crigler Najjar Syndrome (CNS) Type 2 is an uncommon genetic disorder characterised by non-haemolytic unconjugated hyperbilirubinemia. It is caused by mutations in the UGT1A1 gene which codes for the enzyme uridine diphosphate glucoronosyl transferase- 1,
Prabhat Kumar   +4 more
doaj   +1 more source

ケイカチュウ ニ イッカセイ コウビリルビン ケッショウ オ テイシタ ネフローゼ ショウコウグン ノ 2レイ [PDF]

open access: yes, 2004
We present two patients with idiopathic nephrotic syndrome who showed temporary indirect hyperbilirubinemia during the course of treatment with immunosuppressant drugs and/or steroids.
Liang Lijun
core   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

open access: yesAngewandte Chemie International Edition, EarlyView.
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Martin Pfeiffer   +4 more
wiley   +1 more source

Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae

open access: yesmBio
In all kingdoms of life, the enzyme uridine diphosphate-glucose pyrophosphorylase (UGP) occupies a central role in metabolism, as its reaction product uridine diphosphate-glucose (UDP-Glc) is involved in various crucial cellular processes.
Isabel Ramón Roth   +6 more
doaj   +1 more source

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

open access: yesFrontiers in Pharmacology, 2019
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies.
Mei-Ling Han   +12 more
doaj   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

open access: yes, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

open access: yesThe Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan   +13 more
wiley   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

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