Results 11 to 20 of about 11,858 (187)

Elucidation of Sulforaphane-Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling. [PDF]

Mol Nutr Food Res
Sulforaphane (SFN) is an isothiocyanate derived from broccoli and is related to various health‐promoting effects. By using metabolic profiling on the hepatoblastoma cell line HepG2 several effects on pathways such as TCA cycle, urea cycle and redox metabolism through SFN were identified.
Bieß N, Humpf HU, Behrens M, Gerdemann A.   +3 more
europepmc   +2 more sources

Age-Dependent Metabolomic Signatures of Dietary Restriction in Mice. [PDF]

Aging Cell
Elevated hepatic glutathione (GSH) and 3‐hydroxybutyrate (3‐HB) levels in all ages of mice demonstrate an enhanced protection against oxidative stress and improvement in energy metabolism during chronic dietary restriction (DR). However, high protein or muscle degradation in liver of young mice, and large accumulation of hepatic glycogen and excessive ...
Lee JS, Arachchige VHJH, Kim EH, Bang E, Hong YS.   +4 more
europepmc   +2 more sources

Identification of sucrose synthase from Micractinium conductrix to favor biocatalytic glycosylation

Frontiers in Microbiology, 2023
Sucrose synthase (SuSy, EC 2.4.1.13) is a unique glycosyltransferase (GT) for developing cost-effective glycosylation processes. Up to now, some SuSys derived from plants and bacteria have been used to recycle uridine 5′-diphosphate glucose in the ...
Kai Chen, Lei Lin, Ruiqi Ma, Jiajie Ding, Huayi Pan, Yehui Tao, Yan Li, Honghua Jia   +7 more
doaj   +1 more source

The function of uridine diphosphate glucose pyrophosphorylase in the lyophilization-stress response of Lactobacillus acidophilus

Annals of Microbiology, 2022
Purpose Uridine diphosphate glucose pyrophosphorylase (UGPase) plays an important role in glucose metabolism, catalyzing the reversible formation and decomposition of UDP-glucose (UDPG).
Chaoran Xia, Xiaoqun Zeng, Liuyang Peng, Daodong Pan, Zhen Wu, Yuxing Guo, Zhendong Cai   +6 more
doaj   +1 more source

Structural characterisation of nucleotide sugar short-chain dehydrogenases/reductases from the thermophilic pseudomurein-containing methanogen Methanothermobacter thermautotrophicus ΔH. [PDF]

FEBS J
Nucleotide sugar short‐chain dehydrogenases/reductases (NS‐SDRs) are involved in pseudomurein and capsular polysaccharide formation in methanogenic Archaea. Methanothermobacter thermautotrophicus possesses several NS‐SDRs labelled Mth375, Mth380, Mth373, Mth631 and Mth1789.
Carbone V, Schofield LR, Edwards PJB, Sutherland-Smith AJ, Ronimus RS.   +4 more
europepmc   +2 more sources

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +1 more source

Cloning cDNA and functional characterization of UDP-glucose pyrophosphorylase in Dendrobium officinale

Biologia Plantarum, 2017
Dendrobium officinale is a traditional Chinese medicinal herb that produces promising bioactive polysaccharides. However, the biosynthetic pathway of polysaccharides in this herb remains to be elucidated. The uridine diphosphate glucose pyrophosphorylase
R.-L. Wan, J. Sun, T. He, Y.-D. Hu, Y. Zhao, Y. Wu, Z. Chun   +6 more
doaj   +1 more source

Immobilization of the Highly Active UDP-Glucose Pyrophosphorylase From Thermocrispum agreste Provides a Highly Efficient Biocatalyst for the Production of UDP-Glucose

Frontiers in Bioengineering and Biotechnology, 2020
Biocatalysis that produces economically interesting compounds can be carried out by using free enzymes or microbial cells. However, often the cell metabolism does not allow the overproduction or secretion of activated sugars and thus downstream ...
Antje Kumpf, Antje Kumpf, Antje Kumpf, Daria Kowalczykiewicz, Daria Kowalczykiewicz, Katarzyna Szymańska, Maria Mehnert, Isabel Bento, Aleksandra Łochowicz, André Pollender, Andrzej Jarzȩbski, Andrzej Jarzȩbski, Dirk Tischler   +12 more
doaj   +1 more source

GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction

Platelets, 2023
GALE gene encodes the uridine diphosphate [UDP]-galactose-4-epimerase, which catalyzes the bidirectional interconversion of UDP-glucose to UDP-galactose, and UDP-N-acetyl-glucosamine to UDP-N-acetyl-galactosamine.
Ana Marín-Quílez, Christian A. Di Buduo, Rocío Benito, Alessandra Balduini, José Rivera, Jose Maria Bastida   +5 more
doaj   +1 more source

In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids

Molecules, 2013
Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by
Ifedayo Victor Ogungbe, William N. Setzer   +1 more
doaj   +1 more source