Results 1 to 10 of about 7,606 (183)

SsAGM1-Mediated Uridine Diphosphate-N-Acetylglucosamine Synthesis Is Essential for Development, Stress Response, and Pathogenicity of Sclerotinia sclerotiorum [PDF]

Frontiers in Microbiology, 2022
The necrotrophic fungus Sclerotinia sclerotiorum is a devastating pathogen. S. sclerotiorum can cause Sclerotinia stem rot in more than 600 species of plants, which results in serious economic losses every year.
Junting Zhang, Kunqin Xiao, Maoxiang Li, Hanlong Hu, Xianghui Zhang, Jinliang Liu, Hongyu Pan, Yanhua Zhang   +7 more
doaj   +4 more sources

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis [PDF]

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +2 more sources

Biosynthesis of uridine diphosphate N-Acetylglucosamine: An underexploited pathway in the search for novel antibiotics? [PDF]

IUBMB Life, 2022
AbstractAlthough the prevalence of antibiotic resistance is increasing at an alarming rate, there are a dwindling number of effective antibiotics available. Thus, the development of novel antibacterial agents should be of utmost importance. Peptidoglycan biosynthesis has been and is still an attractive source for antibiotic targets; however, there are ...
Wyllie JA, McKay MV, Barrow AS, Soares da Costa TP.   +3 more
europepmc   +4 more sources

Toxin ζ Reduces the ATP and Modulates the Uridine Diphosphate-N-acetylglucosamine Pool. [PDF]

Toxins (Basel), 2019
Toxin ζ expression triggers a reversible state of dormancy, diminishes the pool of purine nucleotides, promotes (p)ppGpp synthesis, phosphorylates a fraction of the peptidoglycan precursor uridine diphosphate-N-acetylglucosamine (UNAG), leading to unreactive UNAG-P, induces persistence in a reduced subpopulation, and sensitizes cells to different ...
Moreno-Del Álamo M, Tabone M, Muñoz-Martínez J, Valverde JR, Alonso JC.   +4 more
europepmc   +7 more sources

Uridine diphosphate N-acetylglucosamine orchestrates the interaction of GlmR with either YvcJ or GlmS in Bacillus subtilis. [PDF]

Sci Rep, 2020
AbstractIn bacteria, glucosamine-6-phosphate (GlcN6P) synthase, GlmS, is an enzyme required for the synthesis of Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a precursor of peptidoglycan. In Bacillus subtilis, an UDP-GlcNAc binding protein, GlmR (formerly YvcK), essential for growth on non-glycolytic carbon sources, has been proposed to ...
Foulquier E, Pompeo F, Byrne D, Fierobe HP, Galinier A.   +4 more
europepmc   +5 more sources

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica. [PDF]

Acta Crystallogr F Struct Biol Commun, 2015
Uridine diphosphateN-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final step in the synthesis of UDP-GlcNAc, which is involved in cell-wall biogenesis in plants and fungi and in protein glycosylation. Small-molecule inhibitors have been developed against UAP fromTrypanosoma bruceithat target an allosteric pocket to provide selectivity over ...
Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD.   +6 more
europepmc   +4 more sources

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei. [PDF]

ACS Chem Biol, 2013
Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many organisms including Trypanosoma brucei, the etiological agent of Human African Trypanosomiasis. High-throughput screening of recombinant T. brucei UAP identified a UTP-competitive inhibitor with
Urbaniak MD, Collie IT, Fang W, Aristotelous T, Eskilsson S, Raimi OG, Harrison J, Navratilova IH, Frearson JA, van Aalten DM, Ferguson MA.   +10 more
europepmc   +5 more sources

Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). [PDF]

PLoS ONE, 2013
O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events.
Xiaofeng Ma, Pi Liu, Hui Yan, Hong Sun, Xiaoyan Liu, Feng Zhou, Lei Li, Yi Chen, Musleh M Muthana, Xi Chen, Peng G Wang, Lianwen Zhang   +11 more
doaj   +11 more sources

Hypothetical protein CuvA (Rv1422) from Mycobacterium tuberculosis H37Rv interacts with uridine diphosphate N-acetylglucosamine as a key precursor of cell wall

Applied Biological Chemistry, 2023
Mycobacterium tuberculosis CuvA (Rv1422, MtCuvA) has previously been suggested that it may play a critical role in nutrient utilization and cell wall synthesis required for physiological adaptation in a host cell, but its biochemical details remain ...
Yoon Chae Jeong, Jihyun Park, Yu Jeong Cheon, Ki Seog Lee   +3 more
doaj   +2 more sources

ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis [PDF]

mAbs
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation.
Ruiqiang Sun, Miaomiao Chai, Jiahao Man, Guiju Yang, Hai Shu, Qiancheng Wang, Cong Tian, Linlin Wang, Shanhui Liao, Yifeng Zhang, Yanyan Cao, Lisha Xia, Haili Yang, Ting Zhang, Luoyan Ma, Shenwang Cao, Qiao Gao, Yichen Le, Mingli Shi, Quanxue Li, Yinmao Fan, Hang Zhou   +21 more
doaj   +2 more sources