Results 91 to 100 of about 7,626 (203)
Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
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Journal of Biological Chemistry, 1990 We have isolated a portion of the uridine diphosphate N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-glucosamine-1-phosphate transferase gene (GTR2) from the genome of a tunicamycin-resistant clonal Chinese hamster ovary cell line, 3E11. The genomic fragment was selected by its hybridization to the yeast ALG-7 gene at low stringency.
J R, Scocca, S S, Krag
openaire +2 more sources
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]
, 2012 P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie +3 more
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Toxins, 2014 Toxins of the ζ/PezT family, found in the genome of major human pathogens, phosphorylate the peptidoglycan precursor uridine diphosphate-N-acetylglucosamine (UNAG) leading to unreactive UNAG-3P.
Mariangela Tabone +2 more
doaj +1 more source
, 2005 GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed
Hwang, Bum-Yeol +6 more
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Aberrant O-GlcNAcylated proteins: New perspectives in breast and colorectal cancer
Frontiers in Endocrinology, 2014 Increasing glucose consumption is thought to provide an evolutionary advantage to cancer cells. Alteration of glucose metabolism in cancer influences various important metabolic pathways including the hexosamine biosynthesis pathway (HBP), a relatively ...
Parunya eChaiyawat +5 more
doaj +1 more source
The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.
PLoS Genetics, 2020 The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N ...
Emma B Alme +4 more
doaj +1 more source
Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]
, 2010 Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core +1 more source
The Journal of Clinical Investigation, 2023 Major depressive disorder is a common and devastating psychiatric disease, and the prevalence and burden are substantially increasing worldwide. Multiple studies of depression patients have implicated glucose metabolic dysfunction in the pathophysiology ...
Jun Fan +16 more
doaj +1 more source
Role of N-glycosylation in oral cancer [PDF]
, 2017 Oral squamous cell carcinoma represents more than 90% head and neck cancers with high incidence rate and morbidity. To date, little is known about the molecular mechanisms responsible for OSCC initiation and progression to advanced disease.
Bukhari, Samah
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