Results 31 to 40 of about 7,626 (203)

Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis [PDF]

, 2006
Metabolic engineering has recently been embraced as an effective tool for developing whole-cell biocatalysts for oligosaccharide and polysaccharide synthesis.
Anne Ruffing, Rachel Chen
core   +1 more source

Multi-omics analysis reveals genes and metabolites involved in Bifidobacterium pseudocatenulatum biofilm formation

Frontiers in Microbiology, 2023
Bacterial biofilm is an emerging form of life that involves cell populations living embedded in a self-produced matrix of extracellular polymeric substances (EPS).
Ting Zhang, Ting Zhang, Zongmin Liu, Zongmin Liu, Hongchao Wang, Hongchao Wang, Hao Zhang, Hao Zhang, Hao Zhang, Haitao Li, Haitao Li, Wenwei Lu, Wenwei Lu, Wenwei Lu, Jinlin Zhu, Jinlin Zhu   +15 more
doaj   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim, Levesque, Roger C.   +6 more
core   +2 more sources

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Frontiers in Pharmacology, 2019
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies.
Mei-Ling Han, Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Darren J. Creek, Christopher K. Barlow, Heidi H. Yu, Zhihui Zhou, Jing Zhang, Jian Li, Jian Li   +12 more
doaj   +1 more source

PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis.

PLoS Pathogens, 2019
Bacterial pathogens have evolved strategies that enable them to invade tissues and spread within the host. Enterococcus faecalis is a leading cause of local and disseminated multidrug-resistant hospital infections, but the molecular mechanisms used by ...
Yusibeska Ramos, Jorge Rocha, Ana L Hael, Jordi van Gestel, Hera Vlamakis, Colette Cywes-Bentley, Juan R Cubillos-Ruiz, Gerald B Pier, Michael S Gilmore, Roberto Kolter, Diana K Morales   +10 more
doaj   +1 more source

Galactose Epimerase Deficiency: Expanding the Phenotype [PDF]

, 2017
Galactose epimerase deficiency is an inborn error of metabolism due to uridine diphosphate-galactose-4'-epimerase (GALE) deficiency. We report the clinical presentation, genetic and biochemical studies in two siblings with generalized GALE deficiency ...
A Alano, DJ Lefeber, IB Sardharwalla, J Charlwood, J Wasilenko, JB Holton, JB Holton, JH Walter, KK Openo, L Sturiale, M Sarkar, MJ Henderson, R Gitzelmann, SS Sparrow, TM Wohlers   +14 more
core   +1 more source

Enzymatic studies of glucuronide formation in impaired liver. II. Activating effect of boiled liver extract on liver glucuronide formation [PDF]

, 1962
The effect of the boiled liver extract on the velocity of 4-methyl umbelliferone lucuronide formation by mouse liver homogenate was studied. The results were as follows: 1.
Taketa, Kazuhisa
core   +1 more source

Agarose Derivatives of Uridine Diphosphate and N-Acetylglucosamine for the Purification of a Galactosyltransferase

Journal of Biological Chemistry, 1972
Abstract The applicability of affinity chromatography for the purification of UDP-galactose: N-acetylglucosamine galactosyltransferase has been evaluated. Three different types of specific adsorbents have been synthesized by reaction of a ligand structurally related to portions of the substrates of the transferase with cyanogen bromide-treated agarose.
R, Barker, K W, Olsen, J H, Shaper, R L, Hill   +3 more
openaire   +2 more sources

Structure-Based Virtual Screening of Pseudomonas aeruginosa LpxA Inhibitors using Pharmacophore-Based Approach

Biomolecules, 2020
Multidrug resistance in Pseudomonas aeruginosa is a noticeable and ongoing major obstacle for inhibitor design. In P. aeruginosa, uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) acetyltransferase (PaLpxA) is an essential enzyme of lipid A ...
Baki Vijaya Bhaskar, Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Gui Yu Zheng, Grigory V. Zyryanov, Wei Gu   +5 more
doaj   +1 more source

Diagnosis of Mucopolysaccharidoses and Mucolipidosis by Assaying Multiplex Enzymes and Glycosaminoglycans

Diagnostics, 2021
Mucopolysaccharidoses (MPS) and mucolipidosis (ML II/III) are a group of lysosomal storage disorders (LSDs) that occur due to a dysfunction of the lysosomal hydrolases responsible for the catabolism of glycosaminoglycans (GAGs).
Nivethitha Arunkumar, Dung Chi Vu, Shaukat Khan, Hironori Kobayashi, Thi Bich Ngoc Can, Tsubasa Oguni, Jun Watanabe, Misa Tanaka, Seiji Yamaguchi, Takeshi Taketani, Yasuhiko Ago, Hidenori Ohnishi, Sampurna Saikia, José V. Álvarez, Shunji Tomatsu   +14 more
doaj   +1 more source