Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. [PDF]
, 2018 O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism.
Chen, Xi +11 more
core
Sugar nucleotide quantification by liquid chromatography tandem mass spectrometry reveals a distinct profile in Plasmodium falciparum sexual stage parasites [PDF]
, 2017 The obligate intracellular lifestyle of Plasmodium falciparum and the difficulties to obtain sufficient amounts of biological material has hampered the study of specific metabolic pathways in the malaria
Dinglasan, Rhoel R. +2 more
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Feedback Inhibition of
Journal of Bacteriology, 1970 The enzyme, l -glutamine d -fructose 6-phosphate amidotransferase (EC 2.6.1.16) of Neurospora crassa , which catalyzes the formation of glucosamine 6-phosphate was shown to be subject to feedback inhibition by uridine diphosphate N -acetyl-
A, Endo, K, Kakiki, T, Misato
openaire +2 more sources
The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity [PDF]
, 2013 Prokaryote-specific sugars, including N,N′-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity.
Imperiali, Barbara +1 more
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Characteristics of Group A Streptococcal Variants Treated with Mitomycin C [PDF]
Japanese Journal of Microbiology, 1973 ABSTRACTTransfers of Streptococcus pyogenes strain T12 in Todd–Hewitt broth containing stepwise increases in amounts of mitomycin C (MC) gave rise to slight changes of their colonial appearances. Variants thus obtained were examined for antibiotic and bile resistances; production of streptolysin‐S, ‐O and deoxyribonuclease; growth in alkaline medium ...
T, Hirano +3 more
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Toxin ζ Triggers a Survival Response to Cope with Stress and Persistence
Frontiers in Microbiology, 2017 Bacteria have evolved complex regulatory controls in response to various environmental stresses. Protein toxins of the ζ superfamily, found in prominent human pathogens, are broadly distributed in nature.
María Moreno-del Álamo +3 more
doaj +1 more source
Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]
, 2018 O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik +8 more
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Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma
Scientific ReportsGlaucoma is the leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form globally and has been linked to mitochondrial dysfunction and energy deficiency.
Yizhen Tang +8 more
doaj +1 more source
Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-based Assays [PDF]
, 2019 MurG (uridine diphosphate-N-acetylglucosamine/N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase) is an essential bacterial glycosyltransferase that catalyzes the N-acetylglucosamine (GlcNAc) transformation of ...
Clemons, William M., Jr. +6 more
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Saccharomyces cerevisiae as a Host for Chondroitin Production
SynBioChondroitin is a glycosaminoglycan that has gained widespread use in nutraceuticals and pharmaceuticals, mainly for treating osteoarthritis. Traditionally, it has been extracted from animal cartilage but recently, biotechnological processes have emerged ...
Márcia R. Couto +3 more
doaj +1 more source