Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]
, 2012 Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar +14 more
core +14 more sources
Urokinase‐Type Plasminogen Activator, an Endogenous Antibiotic [PDF]
The Journal of Infectious Diseases, 2005 Urokinase-type plasminogen activator (uPA) is a serine protease that not only displays fibrinolytic function but also modulates innate and adaptive immune responses. In the present study, we assessed whether uPA acts as an endogenous antibiotic. It has been demonstrated that uPA inhibits growth of Staphylococcus aureus both in vivo and in vitro ...
Tao, Jin +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]
, 2016 Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Carriero, Maria V +9 more
core +1 more source
Tyrosine phosphorylation of human urokinase‐ type plasminogen activator [PDF]
FEBS Letters, 1991 Immunoblatting analysis of purified human urokinase plasminogen activator (u‐PA), gives a positive signal when reacted with anti‐phosphotyrosine monoclonal antibodies (MoAb anti P‐Tyr); competition with α‐phospha‐DL‐tyrosine (P‐Tyr) but not α‐phosphia‐DL‐threonine or serine (P‐Treo, P‐Ser) completely suppresses this signal.
BARLATI, Sergio +3 more
openaire +3 more sources
Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]
, 2001 Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria +10 more
core +1 more source
HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]
, 2015 The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone +6 more
core +1 more source
Multiparity upregulates placental plasminogen and urokinase‐type plasminogen activator
American Journal of Reproductive Immunology, 2017 ProblemMultiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent.
María E. Cortina +3 more
openaire +3 more sources
Characterization of the murine plasminogen/urokinase‐type plasminogen‐activator system [PDF]
European Journal of Biochemistry, 1996 The murine plasminogen/urokinase‐type plasminogen‐activator (u‐PA) system was studied using purified proteins, plasma and endothelioma cells. Recombinant murine u‐PA was obtained as a single‐chain molecule of 45 kDa which was converted to two‐chain u‐PA with plasmin by cleavage of the Lys159‐Ile1 60 peptide bond.
H R, Lijnen, B, Van Hoef, D, Collen
openaire +2 more sources
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]
, 2009 HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher +47 more
core +3 more sources