Results 91 to 100 of about 167,619 (306)
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. [PDF]
, 2017 The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
De Lorenzi, Valentina +11 more
core +3 more sources
Turbulence to order transitions in activity patterned active nematics [PDF]
Phys. Rev. E 111, 035404 (2025)We numerically study two-dimensional active nematics with periodic activity patterning. For stripes of activity, we observe a transition from two-dimensional to one-dimensional active turbulence as the maximum active force and distance between activity stripes increases, followed by a transition to stable vortices ordered antiferromagnetically along ...
arxiv +1 more source
iMetaOmics, EarlyView.This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan +7 more
wiley +1 more source
Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease [PDF]
, 2018 Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis.
Costi, U. +8 more
core
Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells [PDF]
, 2015 : BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal ...
Baltus, Christine B +5 more
core +2 more sources
arXiv, 2023 While bacterial swarms can exhibit active turbulence in vacant spaces, they naturally inhabit crowded environments. We numerically show that driving disorderly active fluids through porous media enhances Darcy's law. While purely active flows average to zero flux, hybrid active/driven flows display greater drift than pure-driven fluids.
arxiv
E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects
JCI Insight, 2021 Fibroproliferative disorders such as systemic sclerosis (SSc) have no effective therapies and result in significant morbidity and mortality. We recently demonstrated that the C-terminal domain of endostatin, known as E4, prevented and reversed both ...
Shailza Sharma +9 more
doaj +1 more source
Obesity, EarlyView.In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton +6 more
wiley +1 more source
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]
, 2009 PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra +4 more
core +2 more sources
Multi-Label Activity Recognition using Activity-specific Features and Activity Correlations [PDF]
arXiv, 2020 Multi-label activity recognition is designed for recognizing multiple activities that are performed simultaneously or sequentially in each video. Most recent activity recognition networks focus on single-activities, that assume only one activity in each video.
arxiv