Results 11 to 20 of about 167,619 (306)

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines [PDF]

Journal of Neuroinflammation, 2019
Background Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias, Elisabetta Mantuano   +8 more
doaj   +3 more sources

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage [PDF]

Brain Hemorrhages, 2020
Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study.
Zhe Kang Law, Michael Desborough, Kamini Rakkar, Philip M. Bath, Ulvi Bayraktutan, Nikola Sprigg   +5 more
doaj   +3 more sources

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. [PDF]

PLoS ONE, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Tina K Koch, Michael Reuter, Diana Barthel, Sascha Böhm, Jean van den Elsen, Peter Kraiczy, Peter F Zipfel, Christine Skerka   +7 more
doaj   +3 more sources

Crystal structure and cellular functions of uPAR dimer

Nature Communications, 2022
The structural basis for urokinase-type plasminogen activator receptor (uPAR) dimerization is not understood. Here, the authors solve the crystal structure of soluble uPAR dimers, identifying substantial structural changes compared to the monomer.
Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Yingping Cao, Liqing Chen, Longguang Jiang, Cai Yuan, Mingdong Huang   +9 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Values of serum PCT, suPAR combined with severity scores for evaluating prognosis of septic shock patients

Romanian Journal of Laboratory Medicine, 2021
Background: To explore the values of serum procalcitonin (PCT), soluble urokinase-type plasminogen activator receptor (suPAR) combined with APACHE II and SOFA scores for evaluating the prognosis of septic shock patients.
Wang Wenxin, Jie Yingxin, Zhou Jia
doaj   +1 more source

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Düzce Tıp Fakültesi Dergisi, 2021
Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt, Engin Şebin, Sibel İba Yılmaz, Ali Batur, Orhan Delice, Omer Karasahin, Kadir Küçükceran   +6 more
doaj   +1 more source

Tyrosine phosphorylation of human urokinase‐ type plasminogen activator [PDF]

FEBS Letters, 1991
Immunoblatting analysis of purified human urokinase plasminogen activator (u‐PA), gives a positive signal when reacted with anti‐phosphotyrosine monoclonal antibodies (MoAb anti P‐Tyr); competition with α‐phospha‐DL‐tyrosine (P‐Tyr) but not α‐phosphia‐DL‐threonine or serine (P‐Treo, P‐Ser) completely suppresses this signal.
BARLATI, Sergio, PARACINI F, BELLOTTI D, DE PETRO, Giuseppina   +3 more
openaire   +4 more sources

Functional, pathogenic, and pharmacological roles of protein folding intermediates

Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023
Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley   +1 more source

Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels [PDF]

The Ukrainian Biochemical Journal, 2013
Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades.
V. A. Tkachuk, O. S. Plekhanova, I. B. Beloglazova, E. V. Parfenova   +3 more
doaj   +1 more source