Results 21 to 30 of about 167,619 (306)
Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Кардиоваскулярная терапия и профилактика, 2021 The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina +5 more
doaj +1 more source
Future Directions for Active Matter on Ordered Substrates [PDF]
EPL 139, 27001 (2022), 2022 Active matter is a term encompassing particle-based assemblies with some form of self-propulsion, including certain biological systems as well as synthetic systems such as artificial colloidal swimmers, all of which can exhibit a remarkable variety of new kinds of nonequilibrium phenomena.
arxiv +1 more source
Characterization of the murine plasminogen/urokinase‐type plasminogen‐activator system [PDF]
European Journal of Biochemistry, 1996 The murine plasminogen/urokinase‐type plasminogen‐activator (u‐PA) system was studied using purified proteins, plasma and endothelioma cells. Recombinant murine u‐PA was obtained as a single‐chain molecule of 45 kDa which was converted to two‐chain u‐PA with plasmin by cleavage of the Lys159‐Ile1 60 peptide bond.
H. Roger Lijnen +2 more
openaire +3 more sources
Separation and characterization of nonphosphorylated and serine-phosphorylated urokinase. Catalytic properties and sensitivity to plasminogen activator inhibitor type 1. [PDF]
, 1992 Urokinase synthesized by human A431 epidermoid carcinoma cells is phosphorylated on serine (Mastronicola, M. R., Stoppelli, M. P., Migliaccio, A., Auricchio, F., and Blasi, F. (1990) FEBS Lett. 266, 109-114).
D. De Cesare +7 more
core +1 more source
Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis
Haematologica, 2012 Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix +14 more
doaj +1 more source
The chicken urokinase-type plasminogen activator gene
Fibrinolysis, 1989 The chicken urokinase-type plasminogen activator (uPA) cDNA and gene have been isolated and the complete nucleotide sequence of each established. cDNA sequence and Northern blot RNA analysis indicate that the chicken uPA mRNA is approximately 2500 nucleotides in size and contains a large 3'-noncoding region (998 nucleotides).
Jay L. Degen +3 more
openaire +4 more sources
Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]
, 2016 Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Carriero, Maria V +9 more
core +1 more source
Oncology Letters, 2017 The soluble urokinase-type plasminogen activator receptor (suPAR) and the urokinase-type plasminogen activator receptor (uPAR) have been proposed as useful biomarkers of tumor progression. Recently, suPAR was associated with chemoresistance in lung cancer. However, its clinical significance in leukemia has not previously been investigated.
Haizhen Ma +6 more
openaire +4 more sources
Proenzyme to urokinase‐type plasminogen activator in the mouse in vivo [PDF]
FEBS Letters, 1985 We have investigated whether urokinase‐type plasminogen activator (u‐PA) is present in the mouse in vivo as the proenzyme or as the active enzyme. u‐PA in extracts of various murine tissues was of a one‐polypeptide chain form with an electrophoretic mobility indistinguishable from purified proenzyme (pro‐u‐PA), as demonstrated by SDS‐polyacrylamide gel
L.S. Nielsen +5 more
openaire +3 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source