Results 21 to 30 of about 75,327 (314)
Düzce Tıp Fakültesi Dergisi, 2021 Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types.
Mahmut Şenyurt +6 more
doaj +1 more source
Functional, pathogenic, and pharmacological roles of protein folding intermediates
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Protein expression and function in eukaryotic cells are tightly harmonized processes modulated by the combination of different layers of regulation, including transcription, processing, stability, and translation of messenger RNA, as well as assembly, maturation, sorting, recycling, and degradation of polypeptides.
Emiliano Biasini, Pietro Faccioli
wiley +1 more source
Tyrosine phosphorylation of human urokinase‐ type plasminogen activator [PDF]
FEBS Letters, 1991 Immunoblatting analysis of purified human urokinase plasminogen activator (u‐PA), gives a positive signal when reacted with anti‐phosphotyrosine monoclonal antibodies (MoAb anti P‐Tyr); competition with α‐phospha‐DL‐tyrosine (P‐Tyr) but not α‐phosphia‐DL‐threonine or serine (P‐Treo, P‐Ser) completely suppresses this signal.
BARLATI, Sergio +3 more
openaire +4 more sources
Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels [PDF]
The Ukrainian Biochemical Journal, 2013 Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades.
V. A. Tkachuk +3 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Кардиоваскулярная терапия и профилактика, 2021 The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and ...
K. A. Rubina +5 more
doaj +1 more source
Characterization of the murine plasminogen/urokinase‐type plasminogen‐activator system [PDF]
European Journal of Biochemistry, 1996 The murine plasminogen/urokinase‐type plasminogen‐activator (u‐PA) system was studied using purified proteins, plasma and endothelioma cells. Recombinant murine u‐PA was obtained as a single‐chain molecule of 45 kDa which was converted to two‐chain u‐PA with plasmin by cleavage of the Lys159‐Ile1 60 peptide bond.
H. Roger Lijnen +2 more
openaire +3 more sources
Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]
, 2016 Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Carriero, Maria V +9 more
core +1 more source
Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis
Haematologica, 2012 Background We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation.Design and Methods Circulating microparticles ...
Romaric Lacroix +14 more
doaj +1 more source
The chicken urokinase-type plasminogen activator gene
Fibrinolysis, 1989 The chicken urokinase-type plasminogen activator (uPA) cDNA and gene have been isolated and the complete nucleotide sequence of each established. cDNA sequence and Northern blot RNA analysis indicate that the chicken uPA mRNA is approximately 2500 nucleotides in size and contains a large 3'-noncoding region (998 nucleotides).
Jay L. Degen +3 more
openaire +4 more sources