Melatonin and the Dental Pulp: A Scoping Review
International Endodontic Journal, EarlyView.ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer +2 more
wiley +1 more source
SP235SOLUBLE UROKINASE TYPE PLASMINOGEN ACTIVATOR RECEPTOR AS A PREDICTOR OF CHRONIC KIDNEY DISEASE [PDF]
, 2016 Ana Carina Ferreira +3 more
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The Journal of Physiology, EarlyView.Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira +3 more
wiley +1 more source
Elevated levels of serum urokinase plasminogen activator predict poor prognosis in hepatocellular carcinoma after resection [PDF]
, 2019 Ming‐Chao Tsai +6 more
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The FASEB Journal, Volume 40, Issue 3, 15 February 2026.Fetal‐placental communication was explored by comparing protein abundances in paired umbilical artery and vein samples, using the SomaLogic 5000‐plex platform. 766 proteins were identified as released by the placenta, largely supported by placental gene expression patterns reported in transcriptomic studies.
Hilde Bastøe Sellevoll +6 more
wiley +1 more source
The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG [PDF]
, 2000 Maribel Parra +4 more
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Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer +4 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao +8 more
wiley +1 more source
Quantitative Real-Time Reverse Transcription-PCR Assay for Urokinase Plasminogen Activator, Plasminogen Activator Inhibitor Type 1, and Tissue Metalloproteinase Inhibitor Type 1 Gene Expressions in Primary Breast Cancer [PDF]
, 2002 Remedios Castelló +7 more
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