Results 101 to 110 of about 99,653 (320)
A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]
, 2019 Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D. +18 more
core +5 more sources
Journal of the National Cancer Institute, 2002 BACKGROUND Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients.
M. Look +39 more
semanticscholar +1 more source
iMetaOmics, EarlyView.This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan +7 more
wiley +1 more source
Zhongguo linchuang yanjiuObjective： To compare the clinical efficacy and safety of AngioJet thrombectomy with sequential low-dose urokinase thrombolysis versus catheter-directed thrombolysis(CDT) in the treatment of acute iliofemoral deep venous thrombosis (DVT).
WANG Youjin, XU Xiangxian, ZHOU Tao, MIAO Qinghai, SHAO Zefeng
doaj +1 more source
Urokinase and dialysis therapy [PDF]
Kidney International, 2000 To the Editor: In a recent review by Schwab and Beathard on hemodialysis catheters, the authors did not acknowledge the value of systemic urokinase infusion to open clotted catheters1. Although they admit that the infusion appears to be safe and less expensive than either fibrin sheath stripping or catheter exchange, they also state that the ...
openaire +2 more sources
Obesity, EarlyView.In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton +6 more
wiley +1 more source
Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]
, 2014 Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P. +2 more
core
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]
, 2009 PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra +4 more
core +2 more sources
Chemical and Pharmaceutical Bulletin, 1974 The metabolic fate of 131I-urokinase in rats and dogs was investigated. The radioactivity in the blood of both animals after intravenous administration rapidly decreased in early stage, followed by a slow decrease of the radioactivity. When 131I-urokinase was given into rats by intravenous infusion, the peak of radioactivity in the blood was found at ...
Shingo Tanaka +5 more
openaire +4 more sources
New England Journal of Medicine, 1998 BACKGROUND Recent controlled trials suggest that thrombolytic therapy may be an effective initial treatment for acute arterial occlusion of the legs. A major potential benefit of initial thrombolytic therapy is that limb ischemia can be managed with less
K. Ouriel, F. Veith, A. Sasahara
semanticscholar +1 more source