Results 91 to 100 of about 46,705 (226)

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis [PDF]

, 2010
Background: Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulfilled by membrane-associated ...
Olivier Gires, Muehlenweg Bernd, Pamela Zengel, Muehlenweg, Bernd, Gires, Olivier, Ramp, D., Gires, O., Alexander Berghaus, Gires Olivier, Mack, Brigitte, Zengel, Pamela, Zahler, Stefan, Muehlenweg, B., Diana Ramp, Stefan Zahler, Mack, B., Bernd Muehlenweg, Zahler, S., Berghaus Alexander, Mack Brigitte, Zengel, P., Suna Schmitz, Berghaus, Alexander, Schmitz, Suna, Schmitz, S., Ramp, Diana, Schmitz Suna, Zahler Stefan, Zengel Pamela, Brigitte Mack, Ramp Diana, Berghaus, A.   +31 more
core   +2 more sources

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
A series of Ir(III) complexes (Ir‐1‐Ir‐4) based on imidazole derivatives provide a new afterglow luminescence mechanism. The work expands the range of afterglow luminescence frameworks to overcome: (i) a lack of new afterglow scaffolds; (ii) the dependence on initial external light activation; and (iii) aggregation‐caused quenching.
Zihan Wu, Liping Zhang, Ziwei Wang, Yachao Wang, Gelin Xu, Feng Chi, Dongxia Zhu, Martin R. Bryce, Ben Zhong Tang, Lijie Ren   +9 more
wiley   +2 more sources

Diabetes decreases patency of tunneled catheters in hemodialysis patients after first effective thrombolysis with urokinase

Renal Failure, 2018
Introduction: Fibrinolysis is one of the methods extending the use of vascular access in patients with tunneled venous catheters thrombosis. The aim of this study was to assess one-year maintenance of tunneled catheters patency after first effective ...
Dominika Wójtowicz, Dominika Cholewa, Anna M. Faba, Beata Domańska, Joanna Kokoszka, Konrad Kopacz, Rafał Ficek, Tomasz Irzyniec, Sylwia E. Rotkegel, Jerzy Chudek   +9 more
doaj   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1289-1297, December 2026.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator

, 1985
Controlled extracellular proteolysis is catalyzed in part by the secretion of plasminogen activators. As a step in the study of the expression of these enzymes in mouse tissues, we have isolated five cDNAs encoding the mouse urokinase-type plasminogen ...
Nagamine, Y., Kocher, H. P., Vassalli, Jean-Dominique, Reich, E., Godeau, F., Belin, Dominique, Duvoisin, R. M., Combepine, Chantal   +7 more
core   +1 more source

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Activación y determinación de parámetros cinéticos de la Plasmina Humana y Ovis aries

Revista Mvz Cordoba, 2011
Objetivo. Comparar las cinéticas y activaciones, unificar las purificaciones y determinar las secuencias de los terminales-N de los plasminógenos Ovis aries y humano. Materiales y métodos.
Omaira Cañas, Alfonso Quijano, Fernando Arbeláez   +2 more
doaj   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

Once-daily intrapleural urokinase treatment of complicated parapneumonic effusion in pediatric patients [PDF]

, 2010
In this paper, we describe our experience in the treatment of childhood empyema using urokinase. Patients' ages ranged from 2 to 12 years. Urokinase (dosage: 3,100 IU/kg/day) was diluted in normal saline to produce 1000 IU/ml (maximum dosage 100,000 IU ...
Bianchini, M. A., BERGAMINI, Barbara Maria, Durante, V., Ceccarelli, P. L., Biondini, D., Repetto, P., Cacciari, A.   +6 more
core   +2 more sources

Efficacy of AngioJet thrombectomy with sequential low-dose urokinase thrombolysis in the treatment of acute iliofemoral venous thrombosis

Zhongguo linchuang yanjiu
Objective： To compare the clinical efficacy and safety of AngioJet thrombectomy with sequential low-dose urokinase thrombolysis versus catheter-directed thrombolysis(CDT) in the treatment of acute iliofemoral deep venous thrombosis (DVT).
WANG Youjin, XU Xiangxian, ZHOU Tao, MIAO Qinghai, SHAO Zefeng
doaj   +1 more source