Results 171 to 180 of about 46,705 (226)

Studies on urokinase. the measurement of urokinase

Clinica Chimica Acta, 1966
Abstract A simple method for the determination of urokinase is described. This was performed by measuring the lysis times of standard fibrin clots containing dilutions of a urine or a urokinase standard preparation. The factors that might influence the results of this assay were investigated.
J, Boomgaard   +3 more
openaire   +2 more sources

Modification of Urokinase

Annals of the New York Academy of Sciences, 1988
Developpement d'un nouveau procede de modification de l'urokinase par la serumalbumine humaine. Avantages de cette urokinase modifiee: resistance a la chaleur, a la pepsine et a un inhibiteur placentaire de l ...
B Z, Shi, G D, Mao, Z P, Xiong
openaire   +2 more sources

Magnetic urokinase: Targeting of urokinase to fibrin clot

Biochemical and Biophysical Research Communications, 1988
A plasminogen activator of human origin, urokinase, was endowed with magnetic property. The magnetic urokinase was composed of magnetite, polyethylene glycol derivative and urokinase, and dispersed in saline. Its particle size of magnetite was approximately 30-60 nm.
Tatsuyuki Yoshimoto   +5 more
openaire   +2 more sources

Studies on Metabolism of Urokinase and Mechanism of Thrombolysis by Urokinase

Thrombosis and Haemostasis, 1979
SummaryPharmacokinetics of intravenously injected 125I-labeled urokinase (125I-UK) of a molecular weight of 33,000 daltons in normal rabbits and patients with various diseases were investigated. The plasma clearance of 125I-UK in rabbits was described by a biexponential curve within six hours with a half-life of 8 minutes, 2.3 hours, respectively.
T, Ueno, N, Kobayashi, T, Maekawa
openaire   +2 more sources

The kringle stabilizes urokinase binding to the urokinase receptor

Blood, 2003
AbstractThe structural basis of the interaction between single-chain urokinase-type plasminogen activator (scuPA) and its receptor (uPAR) is incompletely defined. Several observations indicated the kringle facilitates the binding of uPA to uPAR. A scuPA variant lacking the kringle (ΔK-scuPA) bound to soluble uPAR (suPAR) with the similar “on-rate” but ...
Khalil, Bdeir   +7 more
openaire   +2 more sources

Urokinase and Single-Chain Urokinase-Type Plasminogen Activator (Pro-urokinase)

2001
The discovery of urokinase (UK) is described in chap. 4. The UK in urine is not a waste product as shown by studies of the fate of intravenous injections of UK, which was found not to be excreted by the kidney (Fletcher et al. 1965). Instead, it is secreted by renal tubular cells (Sappino et al.
openaire   +1 more source

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